No so Benign Heme
This serine protease (eponym) complexes with high molecular weight kininogen and is cleaved by Hageman factor to produce kallikrein
This mutation abnormality confers the best prognosis in myelodysplastic syndromes and is associated with ring sideroblasts.
What is SF3B1?
Measuring this peptide level can help you diagnose acquired von Willebrand disease
What is von Willebrand factor propeptide?
This chromosomal abnormalitiy, other than deletion Y carries a better prognosis than a normal karyotype in MDS per the revised IPSS
What is deletion (11q)?
Vorapaxar is an inhibitor of this particular type of receptor that has a ligand that is actually part of the receptor itself that is cleaved by a protease.
What is protease activated receptor?
These 2 targetable gene mutations carry a "high molecular risk" for Myelofibrosis per the MIPSS 70+v2.0.
What are IDH1/IDH2?
This complement regulator is analogous to factor H in facilitating inactivation of C3 except that it is membrane bound
What is membrane cofactor protein?
Name the 4 mutations that classify AML as "high-risk" per the Europenian Leukemia Net classification?
What are RUNX1, ASXL1, TP53 and FLT3-ITD (high AR)?
This histiocytic disorder has emperipolesis as a pathognomonic finding on the biopsy
What is Rosai-Dorman disease?
Gemtuzumab Ozogamicin is a CD33 ADC, when combined with 7+3 had the most pronounced survival advantage in this subtypes of AML.
What are core binding factor AML [Inv16 and t(8;21)]?