Bacterial Therapy
The goal of all mechanisms of bacterial therapy
What is tumor suppression?
The type of antigens that cancers produce
What is neoantigens?
The reason why bacteria should be attenuated
What is decreased toxicity?
The company that created iNeST
What is Genentech?
Tumor tissues are typically oxygenated or deoxygenated?
What is deoxygenated?
The major advantage of bacterial therapy against tumors
What is specificity?
The human version of the MHC molecule
What is HLA? (human leukocyte antigen)
Can bacteria be used to deliver anticancer agents?
What is yes!
The neoantigen definition
What is a mutated self-antigen?
The first scientist who studied using killed bacteria to fight cancer during the 19th century
What is William B Coley?
The process at which chemotaxis helps bacterial therapy
What is Bacterial sensing & invasion?
The MHC class categorization that is presented when antigens are derived from inside the cell
What is MHC class I?
Cytotoxic agents native to bacteria that can kill cells
What is bacterial toxins?
The cell type that translates mRNA into neoantigens
What is dendritic cells?
The types of T-cells that are most frequently detected to target cancers using neoantigen vaccine
What is CD4?
The mechanism in which tumor microenvironment aids bacterial growth
What is shielding environment?
The type of T-cell that are activated during bacterial/viral infection
What is CD8 and CD4?
Type of cells that respond most effectively to chemotherapy
What is fast-dividing cells?
The process in which immunogenic neoantigens are identified
What is sequencing or bioinformatics?
The full name of MHC
What is major histocompatibility complex?
The type of bacteria that cannot effectively replicate in tumor regions
What is aerobic bacterium?
The T-cell type that binds to MHC class II
What is CD4?
The purpose of engineering bacteria so that they can't produce their own nutrients
What is to target dead tissue?
The most amount of neoantigens that have been encoded into one mRNA strand
What is ten?
The common surgical practice done when removing tumors during the 18th & 19th centuries
What is open wounds?