Thiamine

Disease States

100

Disease from overconsumption, causes increased elimination and decreased absorption of thiamine

Alcoholism

200

Pain and paresthesias of the legs, with no injury caused, stemming from not enough vitamin B1

Peripheral neuropathy

300

Dry or wet, this disease is characterized by heart or CNS effects of thiamine deficiency

Beriberi

400

Vitamin B1 deficiency can lead to Korsakoff Psychosis, defined as confabulation, retrograde and antegrade what?

Amnesia

500

This syndrome, named after the area of the brain responsible for speech comprehension, results from low levels of thiamine

Wernicke's Syndrome

Biological Roles

100

Possibly repel these pesky insects that bite, so itchy!

Mosquitos

200

Involved in the conversion of conversion of carbohydrates into what?

Energy

300

Assisting 3 enzymes, thiamine is also called what?

Coenzyme

400

Assists in the production of this, which interacts with nicotinic receptors

Acetylcholine

500

Microsomal detoxification is the metabolism of what, when you have too much of it?

Alcohol

Deficiency

100

Two types of thiamine deficiencies, primary and what?

Secondary

200

This, a term for impaired kidney function, can lead to vitamin B1 deficiency

Renal Disease

300

This disease is attributed to breastfeeding infants from thiamine deficient mothers in poor countries.

neurological impairment

400

Treatment of this due to thiamine deficiency is 5-20mg/day of thiamine

Metabolism errors

500

This metabolic disease, due to impaired liver enzyme pyruvate dehydrogenase is inborn and leads to vitamin B1 deficiency

Lactic acidosis

Interactions

100

Amoxicillin, penicillin, and doxycycline are all what general class of medication?

Antibiotics

200

Thiamine may decrease the side effects of this anti-motion sickness drug

Scopolamine

300

Loop, thiazide, and potassium sparring ______ reduce B1 levels in the body

Diuretics

400

B1 actually may increase efficacy when given with this class of drugs, hint: includes tricyclic

Antidepressants 

500

This drug, which inhibits the Na/K ATPase in the mycardium, reduces cardiac cell absorption of B1

Digoxin

Sources

100

This pink-fleshed fish, found in the Atlantic, has 15.33% of daily B1 requirements

Salmon

200

Name the highest non-vegetarian dietary source of B1

Cooked ground pork

300

Sausages are not good sources of thiamine, because they contain _____ based preservatives, that inactivate thiamine

Sulfite and nitrite

400

White flour must be what, to reach levels of B1 equivalent to whole grains

Enriched

500

Blueberries contain this, that inactivates thiamine

Thiaminase