MOA
Proguanil inhibits this enzyme to block thymidine synthesis
What is dihydrofolate reductase?
Malarone can cause this side effect, which is due to improper reabsorption of water mainly in the large intestine
What is diarrhea?
Malarone is given in this manner, PO for short
What is by mouth? (Per os)
The correct sequence of the life cycle of the malaria parasite
Hint: "Think -oites"
What is
Sporozoites, Merozoites, Trophozoites, Schizonts, Merozoites
Proguanil is this type of drug, meaning it must be processed in the body before it exerts its effect
What is a prodrug?
Malarone can cause this type I hypersensitivity reaction
What is anaphylaxis?
Malarone is indicated if the malaria is resistant to this drug
What is chloroquine?
This organ activates Proguanil into its active form, known as cycloguanil
What is the liver?
Malarone may cause pruritis, also known as this
What is itching?
Daily Double
Malarone may negatively interact with this drug that inhibits epoxide reductase
What is warfarin?
Daily Double
Atovaquone inhibits this, the third cytochrome in the electron transport chain.
What is Cytochrome b-c1?
Malarone may cause this, also known as epistaxis
What are nose bleeds?
Proguanil is metabolized by this liver enzyme
What is CYP450?
Atovaquone has stereoisomers because of the presence of these "special" carbons
What are chiral carbons?
A very serious skin reaction caused by Malarone and certain antibiotics such as penicillins and sulfa drugs
What is Steven's Johnson Syndrome?
In severe cases of malaria, this drug is given instead
What is IV artesunate?