Viva la Vivo
experiments performed within a living organism
what is in vivo?
3D aggregates of pluripotent stem cells that can differentiate into multiple lineages.
What are embryoid bodies?
most abundant protein in the ECM
what is collagen?
cells that produce ECM
what are fibroblasts?
experiments conducted outside a living organism in a controlled environment
What is in vitro?
simple 3D culture technique that uses gravity to encourage cell aggregation
What is the hanging drop method?
glycoproteins that connect cells with collagen fibers in the ECM
what is fibronectin
cells that line blood vessels
what are endothelial cells?
experiments performed on tissues removed from an organism but maintained in a controlled environment
what is ex vivo?
3D structures derived from stem cells and self-organize to recapitulate aspects of tissue architecture
what are organoids?
form networks of web-like structures that resist tensile forces in the basal lamina
what are laminins?
cells that store lipids in the body
what are adipocytes?
experiments or simulations conducted using computational or mathematical models
in silico
protein- or polymer-based material for cells grown in 3D
what is a hydrogel?
solubilized basement membrane extract used in the lab
what is matrigel?
a broad category of immune cells
what are leukocytes?
measurements or labeling performed in the original location of cells or tissues
what is in situ?
platforms that use small channels to precisely control fluid flow, gradients, and cell–cell interactions in culture
what is microfluidics?
ECM protein that gives elasticity to tissues
what are elastins?
multipotent cells can differentiate into multiple connective tissue lineages
what are mesenchymal stem cells?