AntiViral(3)/Retroviral(3)
Acyclovir, Valacyclovir, Oseltamivir & Maraviroc, Raltegravir, Glecaprevir/Pibrentasvir
(Drug Class)
What are antivirals and antiretrovirals?
Zovirax, Valtrex, Tamiflu & Selzentry, Isentress, Mavyret
The only penicillin that is NOT renally dosed.
ALSO: one hepatic.
What is Penicillin VK?
What is Augmentin?
1-2.5 mg/kg/dose q8-12h OR 4-7 mg/kg/dose
What is tobramycin?
Dose of azithromycin IV and PO.
What is 500 mg IV daily for at least 3 days, then 500 mg PO daily to complete 7-10 days of therapy?
OR
500 mg on day 1, followed by 250 mg daily for 4 days.
Possible drug-induced hepatotoxicity with allergic type features
What is maraviroc?
Renal Adjustment
Acyclovir, valacyclovir, oseltamivir, maraviroc
Amoxicillin Dose
What is 500mg-1g q8-12h?
Conventional: 3-5 mg/kg/day in divided doses q8h
OR
5-7 mg/kg/day qd
What is gentamicin?
PO: 250-500 mg q12h or 1000 mg once daily
Drug and interactions.
What is clarithromycin and CYP3A4 and history of QT?
HepB virus reactivation
Coadminister with atazenavir or rifampin
Use caution in patients with Child-Pugh class B- No liver impairment
What is Mavyret (glecaprevir/pibrentasvir)?
Initial Episode of something treated with valacyclovir
What is Valtrex- 1 gram BID for 7-10 days?
(2:1) IM/IV: 1.5-3 g q6h
IV: 3.375g q6h or 4.5g q6-8h (max 18g/day)
What is Unasyn (amp/sul) and Zosyn (pip/taz)?
Adjustments for gentamicin and tobramycin.
Dificid.
What is fidaxomicin- 200 mg BID for 10 days.
May cause nephrotoxicity, neuromuscular blockage and respiratory paralysis, ototoxicity
What are AMGs?
IV treatment for shingles
What is 10-15 mg/kg/dose q8h for 10-14 days?
(PO- 800mg 5x/day for 7-10 days)
Pip/Taz Warnings (2)
What is sodium content should be consider in patients with sodium restriction AND also increased nephrotoxicity when given with vancomycin?
No pregnancy!
Treatment dose in naive pts: 400 mg BID or 1200 mg qd
Treatment experienced pt: 400 mg BID
What is the dose of Raltegravir (Isentress)?
INSTI
Pts with infectious mono develops an erythematous rash with this drug.
What is amoxicillin?
Possibly carcinogenic.
What is metronidazole?