Antidepressants
This side effect is commonly seen in bupropion overdose
Seizure
This visual change is often associated with digoxin toxicity
Halos around lights
This lab value is commonly elevated in valproic acid overdose
Ammonia
This toxic alcohol metabolite is associated with development of acute kidney injury
Oxalate
This antidepressant has been associated with the most overdoses and deaths since 2020.
Bupropion
This lab value is most predictive of morbidity/mortality following a digoxin overdose
Potassium
It does not cross the BBB
This street drug adulterant may cause prolonged sedation and necrotic skin lesions
Xylazine
Name these two common EKG changes seen in buproprion OD
QTc prolongation, QRS widening
This is the recommended initial dose of insulin for management of BB/CCB OD
0.5-1 unit/kg/hr
Name two classes of medications you should use with caution in patients on lithium to avoid toxicity
Thiazides, NSAIDs, ACE/ARB
This medication can be used to treat recurrent/persistent hypoglycemia after sulfonylurea OD
Octreotide
These two patient factors are most associated with development of seizures in bupropion OD
Tachycardia and agitation
This beta blocker is most commonly associated with development of seizures after overdose
Propranolol
What s/sx can help differentiate between serotonin syndrome and NMS?
NMS: lead pipe ridigity, bradykinesia
SS: hyperreflexia, clonus, cogwheel rigidity
1.5 ml/kg
Why does bicarb not usually affect prolonged QRS in bupropion overdose?
Bupropion causes QRS widening via inhibition of gap junctions rather than sodium channel blockade
This lab value is often elevated in CCB OD but not BB OD
This EKG change is most predictive of development of seizures and arrhythmias in TCA OD
Elevated R wave in AVR
Name two ingestions for which you would recommend against activated charcoal
PHAILS