Tralo Package Insert
How is Tralo administered?
Subcutaneous injection
What is the loading dose for adult AD patients?
600mg in 2 300mg injections
What is the name of studies 1-3?
ECZTRA 1-3
How many mg of Tralo is given in the loading dose?
600mg
In trial 3 (Dupixent and TCS) what percent of patients achieved EASI 75 at week 16?
69%
What steroid was given as needed in clinical trials?
Mometasone furoate .1% cream
Can patients with a latex allergy take Tralo?
Yes. The needle cap is not made with natural rubber latex.
What is the MOA for Dupixent?
A human monoclonal igG4 antibody that inhibits IL4 and IL13 signaling by specifically binding to the IL-4R alpha subunit shared by the IL4 and IL13 receptor complexes. Dupi inhibits IL4 signaling via the type1 receptor and both IL4 and il13 signaling through the type 2 receptor.
In trial 3 what percent of Tralo patients achieved a EASI 75 at week 16?
56%
What is the MOA of Tralo?
A fully human IgG4 monoclonal antibody that specifically binds to the type 2 cytokine interleukin IL13 and inhibits it’s interaction with the IL 13 receptor alpha 1 and 2 Subunits.
What was incidence of conjunctivitis in Dupi monotherapy trial?
10%
9% in dupi plus TCS
In trial 3 what percent of Tralo patients achieved the 16 week endpoint measured on the NRS scale?
45%
What should a patient do if they miss a dose of Tralo?
Administer the dose as soon as possible. Thereafter, resume dosing at the regular scheduled time.
What is the generic name for Dupixent?
Dupilumab
At week 32, what percent of patients in Trial 3 achieved a EASI 75?
93% Q2W and 91% Q4W