INDICATIONS
What is trazodone primarily used to treat?
Major depressive disorder.
What common side effect causes sleepiness?
Sedation and somnolence.
What is the brand name of trazodone?
Desyrel.
How should the immediate-release tablet be taken to reduce dizziness and lightheadedness?
Should be taking with food
What neurotransmitter does trazodone inhibit reuptake of?
Serotonin (5-HT).
What condition is trazodone used for off label?
Insomnia.
What side effect can cause dizziness when standing?
Orthostatic hypotension.
What is the generic name?
Trazodone
What should patients avoid because trazodone can cause drowsiness and sedation?
Driving or activities requiring mental alertness coordination.
What receptor does trazodone block that causes drowsiness?
Histamine-1.
Is insomnia an on label or off-label use?
Its an Off label.
Name two stomach related side effects.
Nausea and vomiting
What medication class is contraindicated with trazodone?
MAO inhibitors MAOIs
What should patients avoid while taking trazodone?
Alcohol and other CNS depressants.
What receptor does trazodone block that can cause orthostatic hypotension?
Alpha-1 adrenergic.
What type of medication is trazodone?
Antidepressant.
What rare side effect is associated with sexual function?
Priapism
How long after stopping an MAOI should trazodone generally not be started?
14 days.
How should a patient get up from sitting or lying down?
They should rise slowly.
What happens when trazodone inhibits serotonin reuptake?
Serotonin activity increases.
Name the two indications that is on the coloring page.
Major depressive disorder and insomnia off-label.
What is the boxed warning for trazodone?
Increased risk of suicidal thinking and behavior in children adolescents and young adults 18–24 years old
Name two medications specifically listed as contraindicated with trazodone.
Linezolid and intravenous methylene blue
Why should the patient rise slowly?
To reduce the risk of orthostatic hypotension.
What are the three main targets shown in the mechanism diagram?
Serotonin histamine-1 and alpha-1 adrenergic receptors.