Pharmaceutics II
PPP
Biosystems
Medicinal Chemistry
Miscellaneous
100
Question: The reason for the reduced metabolism of midazolam after 30 minutes compared to no pre-incubation in the 1% Methanol control experiment (Figure 1) is:
A. A lower CYP level after 30 minutes due to enzyme degradation
B. A lower CYP level after 30 minutes due to trapping of boceprevir in the enzyme active site
C. A higher midazolam level after 30 minutes due to degradation of the drug
D. A higher CYP level after 30 minutes due to autoinduction by
A. A lower CYP level after 30 minutes due to enzyme degradation
100
Q: Which of the following is the brand name for metoprolol succinate?
A. Cymbalta
B. Cozaar
C. Lopressor
D. Toprol-XL
D. Toprol-XL
100
This term refers to a patient lying face upward:
A. prone
B. supine
C. proximal
D. inferior
E. deep
B. Supine
100
Question: The definition of Ki is:
A. The concentration of ligand required to increase protein expression by 50%
B. The concentration of ligand required to activate a receptor by 50% over baseline
C. The concentration of ligand required to achieve an IC50 of 50 nM
D. The concentration of ligand required to occupy 50% of the protein binding sites
D. The concentration of ligand required to occupy 50% of the protein binding sites
100
A denser connective tissue surrounding a fasciculus is called the __________.
A. epimysium
B. endomysium
C. perimysium
D. muscular fascia
C. perimysium
200
Question: The estimated IC50 for non-covalent (not mechanism-based or time-dependent) inhibition of CYP3A4 by boceprevir (Figure 1) is:
A. 0.3 µM
B. 1 µM
C. 3 µM
D. 10 µM
D. 10 µM
200
Q: Which of the following are social determinants of health? (Select all that apply)
A. Transportation
B. Life expectancy
C. Literacy
D. Access to health food options
A. Transportation
C. Literacy
D. Access to health food options
200
Which of the following are properties of cardiac muscle? Select all that apply.
A. found in many organs of the body
B. membrane is composed of gap junctions and intercalated disks
C. striated nature
D. multiple nuclei in each cell
B. membrane is composed of gap junctions and intercalated disks
C. striated nature
200
Question: In assigning the chirality of carazolol in Figure 1, which of the following is correct:
A. The hydroxyl is priority group 1 and the CH2-amine is priority group 2
B. The hydroxyl is priority group 2 and the CH2-amine is priority group 3
C. The hydroxyl is priority group 1 and the CH2-amine is priority group 3
D. The hydroxyl is priority group 3 and the CH2-amine is priority group 1
C. The hydroxyl is priority group 1 and the CH2-amine is priority group 3
200
Which of the following would yield accurate BMD estimation results in the event of a primary osteoporosis screening in a pharmacy? [M2 Question]
A. pDEXA
B. CT scan
C. Quantitative ultrasonography
D. Dexa
C. Quantitative ultrasonography
300
Question: Metabolism of boceprevir to metabolite M11 is an example of:
A. Hydroxylation
B. Expoxidation
C. O-Demethylation
D. Glucoronidation
A. Hydroxylation
300
Q: Which of the following is the most correct dosing instructions for Cardizem CD?
A. Take one 180 mg capsule by mouth once daily for angina pectoris
B. Take one 18 mg capsule by mouth once daily for angina pectoris
C. Take one 1.8 mg capsule by mouth once daily for angina pectoris
D. Take one 1800 mg capsule by mouth once daily for angina pectoris
A. Take one 180 mg capsule by mouth once daily for angina pectoris
300
Which of the following best describes afterload as it relates to the cardiovascular system:
a. Left ventricular end-diastolic volume
b. Left ventricular end-systolic pressure
c. The force stored in the arteries that oppose the ejection of blood
d. Right atrial pressure
c. The force stored in the arteries that oppose the ejection of blood
300
Question: Compared to S-carazolol, R-carazolol is:
A. A more than ten times stronger beta2-AR inhibitor because of a better fit in the beta2-AR binding site
B. A more than ten times stronger beta2-AR inhibitor because of a poorer fit in the beta2-AR binding site
C. A more than ten times weaker beta2-AR inhibitor because of a better fit in the beta2-AR binding site
D. A more than ten times weaker beta2-AR inhibitor because of a poorer fit in the beta2-AR binding site
D. A more than ten times weaker beta2-AR inhibitor because of a poorer fit in the beta2-AR binding site
300
Keeping in mind the timeline of disease, when is the optimal time to do a screening exam?
A. When someone is susceptible to a disease
B. When someone is in the preclinical stage of disease
C. When someone is in the clinical stage of disease
D. When someone has started treatment for the disease
B. When someone is in the preclinical stage of disease
400
Question: The decreased Cmax and AUC for boceprevir in subjects who also received St. John's Wort (Table 1) is probably caused by:
A. Induction of CYP enzymes by boceprevir
B. Increased clearance due to inhibition of CYPs by St. John's Wort
C. Induction of CYP enzymes by St. John's Wort
D. Increased clearance due to inhibition of CYPs by boceprevir
C. Induction of CYP enzymes by St. John's Wort
400
Q: You're taking a medication history for a participant at a health fair. The participant is a 47-yo male with a PMH of Type II DM and HTN. His medication list includes aspirin 81mg QD, atorvastatin 10mg QD, metformin 1000mg BID, lisinopril 20mg QD, HCTZ 25mg QAM. What is the indication for the use of atorvastatin 10mg daily?
A. diabetic neuropathy
B. hyperglycemia
C. prevent nephropathy caused by uncontrolled hyperglycemia
D. dyslipidemia
D. dyslipidemia
400
What GI hormone regulates the secretion of trypsin?
Answer: CCK (cholecystokinin)
400
Question: The weaker binding of atenolol to the beta1 AR compared to carvedilol is probably due to:
A. Loss of the positive charge on the amine in atenolol
B. Increased hydrogen bonding of atenolol with the receptor
C. Loss of hydrophobic contacts of atenolol with the receptor
D. The lower molecular weight of atenolol
C. Loss of hydrophobic contacts of atenolol with the receptor
400
The type of epithelium that is found in the lining of the intestines and stomach and may be
ciliated is known as:
A. simple columnar epithelium
B. simple cuboidal epithelium
C. transitional epithelium
D. stratified columnar epithelium
A. simple columnar epithelium
500
Question: Considering all the data, the best concluding statement is:
A. Boceprevir is a CYP substrate, a non-covalent CYP3A4 inhibitor, and a time-dependent CYP3A4 inhibitor.
B. Boceprevir is a CYP3A4 substrate, a non-competitive CYP3A4 inhibitor, and an OATP1B3 inhibitor.
C. Boceprevir is a CYP substrate, has an active M11 metabolite, and is a very weak P-gp inhibitor.
D. Boceprevir is a CYP3A4 substrate, a non-covalent CYP3A4 inhibitor, and an inducer of CYP enzymes.
A. Boceprevir is a CYP substrate, a non-covalent CYP3A4 inhibitor, and a time-dependent CYP3A4 inhibitor.
500
Q: Patient CP is a 47 year old Caucasian female. She has come in for a diet and weight management appointment with you. She has brought in a food diary with 2 days’ worth of entries. You are helping her with ideas on food substitutions so she can reduce her daily calorie consumption. Review the food diary below and select the most appropriate and reasonable recommendation for food substitution to reduce caloric intake from the answer choices below.
D. Eat a cup of fresh strawberries instead of cherry pie
500
The effects of vagal stimulation on the spontaneous depolarization of pacemaker cells is due to
which of the following mechanisms?
a. increasing number of open Na+ channels and increasing number of open Ca2+ channels
respectively
b. increasing number of open K+ channels and decreasing number of open Ca2+ channels
respectively
c. decreasing number of open Na+ channels and increasing number open Ca2+ channels
respectively
b. increasing number of open K+ channels and decreasing number of open Ca2+ channels
respectively
500
Question: Based on a comparison of the structures of atenolol, carazolol and carvedilol, how would you expect atenolol to bind to the beta1 adrenergic receptor?
A. With the amide group of atenolol close to serine 211
B. With the isopropyl group of atenolol close to serine 211
C. With the amine group of atenolol close to serine 211
D. With the hydroxyl group of atenolol close to serine 211
A. With the amide group of atenolol close to serine 211
500
Question: Which of the following statements is the best explanation of the beta1 adrenergic receptor binding affinity of S-carazolol compared to carvedilol?
A. The change in entropy of the ligand upon binding is less negative for carazolol and this contributes to the higher binding affinity of carazolol
B. The loss of several hydrogen bonds in the carazolol complex contributes to the lower binding affinity of carazolol
C. Formation of electrostatic interactions by the additional aromatic ring of carvedilol contributes to the lower binding affinity of carvedilol
D. The change in the configuration of the chiral center of carvedilol contributes to the higher binding affinity of carvedilol
A. The change in entropy of the ligand upon binding is less negative for carazolol and this contributes to the higher binding affinity of carazolol