While not the first Cartoon Network original show, this one was the first one under the "Cartoon Cartoons" label, airing in 1996.
Dexter's Laboratory
DAILY DOUBLE
Gumball Watterson
Amazing World of Gumball
Initially airing in 2001, this cartoon about spies from the Beverly Hills would recieve six seasons, a movie, and an upcoming seventh season.
Totally Spies
Obtuse, Rubber Goose, Green Moose, Guava Juice, Giant Snake, Birthday Cake, Large Fries, Chocolate Shake
Fairly Odd Parents
Timmy Turner, Bubbles, Raven.
Tara Strong
The last of the cartoon cartoons to end, finishing in 2009 after 130 episodes, 4 specials, and a movie.
Ed,Edd, n' Eddy
Stimpy
Ren and Stimpy
Starting in 2015 and airing on Netflix, Nickelodeon, and Disney Channel, this show focuses on two Parisienne teenagers and their double lives as superheroes.
Miraculous: Tales of Ladybug and Cat Noir
Good morning, U.S.A, I got a feeling that it's gonna be a wonderful day.
American Dad
Yakko, Carl Wheezer, Raphael
Rob Paulsen
Releasing in 1997, this TV show is a spinoff of Cow and Chicken, starting off as a segment on that show.
I Am Weasel
Snowball II
The Simpsons
Releasing in 2004, this cartoon focused on five girls, Will, Irma, Taranee, Cornelia, and Hay Lin, who used magical powers relating to the elements to fulfill roles as guardians.
W.I.T.C.H
Five o'clock, get a call to go blading by the skate park down by the mall, but my mom says I gotta prevent hostile aliens from annihilating us all.
My life as a teenage robot.
Buzz Lightyear, Kronk, Joe Swanson
Patrick Warburton
Releasing in 2000, this show focuses on an animal exploring his way through the big city, while avoiding the military.
Sheep in the Big City
Mr. Blik
Catscratch
Airing on Jetix from 2003 to 2006, this show focuses on a secret originization called "The Center", focused on defending the world from supernatural threats.
Martin Mystery
When it seems to be heading for
The final curtain
Cool deduction never fails
Well, that's for certain
The worst of messes
Can become successes
Ducktales
Leonardo, Chris Griffin, Howard the Duck
Seth Green
Before splitting off into its own show, The Grim Adventures of Billy and Mandy was part of "Grim and Evil" with this show.
Evil Con Carne
Azrael
Smurfs
Produced and directed by Steven Spielberg, this 2011 CGI film was an adaptation of the classic adventure comic book.
The Adventures of Tintin.
Hi, I'm Andy, you think I'm kind of clever. I'm taking practical jokes to a whole nother level.
What's with Andy
Mario, Garfield, Emmett Brickowski
Chris Pratt