Immunology history
Credited with the creation of the first small pox vaccine
Edward Jenner
T-cells and B-cells are derived from
Common lymphoid progenitor (CLP)
End result of a cell signaling pathway
effector mechanism
epithelial cells, mucous membranes, and nasal hairs
physical barriers
process of tagging pathogens, marking them for destruction by phagocytes
opsonization
Theory developed by Talmadge that explains how a particular immune cell responds to a particular pathogen
Clonal Selection
Pluripotent cell type found in low concentrations in adult bone marrow
Hematopoetic stem cell (HSC)
Enzyme that removes a phosphate group
common structural motifs found on pathogens like bacteria and fungi that are recognized by PRRs
PAMPs
Initiated by C1 binding to antibody
classical pathway
protection from a contagious disease when a large enough proportion of the population is protected, either through vaccination or previous infection
Herd immunity
Monocytes, basophils, and eosinophils are derived from
common myeloid progenitor (CMP)
G-protein linked receptor that spans the plasma membrane 7 times
chemokine receptor
swelling, heat, pain, loss of function
inflammation
Involves MBL and MASPs
Lectin pathway
by accidentally re-innoculating chickens with old cultures of cholera, Pasteur discovered the benefit of
attenuation
cell type defined by expression of CD3
T-cell
TLR found on the plasma membrane that recognizes flagellin
TLR 5
Thymus and bone marrow
primary lymphoid organs
C3bBb
C3 convertase of the alternative pathway
The observation that serum from immunized animals could transfer immunity to diptheria from one organism to another supported the existence of
humoral immunity
cell type defined by expression of CD4
Helper T-cell
TLR expressed on the endosome that recognizes viral ssRNA
TLR 7 or TLR 8
main bridge between innate and adaptive immunity
dendritic cells
involves C5, C6, C7, C8, and C9
Membrane Attack complex (MAC)