BPH
What does IPSS stand for?
International Prostate Symptom Score
Early vs Delayed is pooled data sourced from how many dutasteride trials?
6
In men with LUTS/BPH prostate growth is
about _____% per year
4.5 - 5%
Name two seizure types
Focal
Generalised
Keppra is indicated as monotherapy in the treatment of ______________________________________
partial onset seizures with or without secondary in patients from 16 years of age with newly diagnosed epilepsy.
Name 2 factors indicating risk of disease progression in BPH patients
1. age ≥ 62
2. IPPS ≥ 8, PV > 40ml, PSA > 1.4 ng/ml,
Qmax <10.6mL/s
In Combat, the reduction in total prostate volume in 48 month was _____% with combination therapy
27%
As many as ______% of Epileptic Seizures are Partial/Focal Seizures
60-75%
What is VPA & CBZ in short for?
VPA - valproic acid/sodium valproate
CBZ - carbamazepine
1 tablet of 500mg is equivalent to
IV ____ ml and
oral solution ____ ml
1. 5 ml
2. 5 ml
What are the 2 common alpha blockers in the market?
1. Harnal
2. Xatral
Combat study was a 4 years, randomised, double-blind study in _____ men _____ years of age with clinical diagnosis of BPH and an IPSS of ______ points
4844, ≥ 50, ≥ 12
What is the 'Title' of Duodart webcast on 1st Sept 2021?
Early vs Delayed : BPH clinical progression and management
Name 2 very common side effects of Keppra
Headache, somnolence, nasopharyngitis
With Keppra, optimal titration is achieved in up to ____ weeks compared to CBZ/VPA in ______ weeks
2 (two)
4 (four)
State 4 complications that may present with BPH disease progression
Symptom deterioration, AUR
BPH related surgery, Recurrent UTI
Renal insufficiency, overflow/urge incontinence
Stone formation
State 4 Duodart brand benefits
1. reduce prostate volume
2. improve symptoms/LUTS/flow
3. sustained symptomatic relief
4. reduce long term risk of AUR and surgery
What is our YTD July value growth for Keppra?
2%
State any 3 considerations when choosing an AED for epileptic patients
seizure type, age
gender
What are the 2 key benefits of Keppra vs VPA?
1. lower risk of MCM
2. VPA is associated with weight gain
3. not been shown to be associated with detrimental effects on neurodevelopment in infants unlike VPA
Many factors influence sexual function in men, including (a) ____ (b) ______ (c) ______ (d) _____
(a) age (b) severity of LUTs
(c) comorbidities (d) comedications
What is the primary endpoint of EvD study?
Proportion of patients achieving a clinically meaningful improvement in IPSS (≥25% reduction from baseline) at mth 48
What is our YTD July growth for Duodart?
(a) value (b) volume
a) 47%
b) 49%
Switching of AEDs in well-controlled epilepsy patients may lead to (a) __ (b)__ (c) __
(a) breakthrough seizures (b) increased seizure frequency (c) increased adverse effects
Name the 2 registries showing study data of high MCM risk associated with VPA vs Keppra
1. EURAP (International Registry of Antiepileptic Drugs and Pregnancy)
2. NAAPR (North American Antiepileptic Drugs and Pregnancy Registry)