Shocking!
Alpha adrenergic agonist that can cause reflex bradycardia
phenylephrine (Neosynephrine)
Effects heart rate. Can have + or - effects.
Chronotropes
Resource for IV drug compatibility
Lexicomp
Normal cardiac output
4-8 L/min
High pressure vessels that carry oxygenated blood to rest of the body
Arteries
First line vasopressor used to treat hypotension from sepsis
norepinephrine (Levophed)
Beta 1/2 adrenergic agonist that can cause hypotension, tachycardia, hypokalemia
Dobutamine
medications that can cause tissue necrosis and have low ph
Vesicants
Based upon cardiac output, but indexed to reflect body size
Cardiac Index
Location of Beta 1 Receptors
Heart
Synthetic anti diuretic hormone
Vasopressin
Phosphodiesterase inhibitor with inotropic and vasodilatory effects
Milrinone
Inhibitory effects to other parts of the body like GI system
Adrenergic Agonists
Average pressure driving blood to the body tissues through one cardiac cycle
Mean Arterial Pressure (MAP)
Vessel length + vessel diameter + blood viscosity
Systemic Vascular Resistance
Medication that has alpha effects at higher doses
Dopamine
Acts on Beta 1 receptors increasing force and rate of heart contraction.
Isoproterenol
Can cause tachycardia and arrhythmias.
Positive Inotropes
0.5-1 mcg/min q min is a common titration rate for
Norepinephrine *follow order*
Heart Rate x Stroke Volume
Cardiac Output
This medication can increase blood sugars and serum lactate
Epinephrine
Can be used as an inotrope or vasopressor
Epinephrine
These are NOT titrated.
Dobutamine, Vasopressin, Milrinone
50 mcg/min is the max dose for these two vasopressors.
Epinephrine and Norepinephrine *follow order*
Preload + Afterload + Contractility