Barriers
Innate Immunity
Adaptive Immunity
Immunity and Vaccination
Mixed Challenge
100

This physical barrier is the body's first line of defence and prevents most pathogens from entering.

Intact Skin

100

This process causes redness, swelling, heat and pain following tissue damage.

Inflammatory Response

100

These lymphocytes mature in the bone marrow and produce antibodies.

B lymphocytes / B cells

100

Receiving antibodies from breast milk is an example of this type of immunity.

Natural Passive Immunity

100

These organs filter lymph and are important sites for antigen recognition by T and B lymphocytes.

Lymph nodes

200

Hydrochloric acid is found here and destroys many pathogens before they reach the intestines.

Hydrochloric acid is this category of barrier

Stomach

Chemical

200

These white blood cells are usually the first phagocytes to arrive at an infection.

Neutrophils

200

These cells release cytokines that activate both B cells and cytotoxic T cells.

T-Helper cells

200

Receiving a vaccine provides this type of immunity.

Artificial active immunity

200

What is the difference between a self-antigen and a non-self antigen?

A self-antigen belongs to the body's own cells, while a non-self antigen originates from foreign organisms or substances.

300

Plants protect themselves using this tough outer layer that reduces pathogen entry.

Waxy cuticle

300

These immune cells engulf pathogens and present their antigens to helper T cells.

Dendritic Cells

300

These proteins specifically bind to antigens on extracellular pathogens.

Antibodies

300

Receiving anti-venom after a snake bite is an example of this type of immunity.

Artificial passive immunity

300

Which type of immune cell is most effective against multicellular parasites such as worms?

Eosinophils

400

Name TWO examples of microbiota that help prevent infection.

Bacteria on the skin

Bacteria in the digestive tract

400

This group of plasma moecules punches holes in bacterial membranes and enhances phagocytosis.

Complement Proteins

400

These cells destroy virus-infected body cells by releasing perforins and granzymes.

Cytotoxic T cells
400

This type of immunity generally lasts longer because memory cells are produced.

Active immunity

400

A virus infects body cells. Which adaptive immune cell will ultimately destroy these infected cells?

cytotoxic T cells

500

Explain why antibiotics can sometimes increase the risk of infection by opportunistic pathogens.

because antibiotics may destroy beneficial microbiota, allowing harmful pathogens to colonise

500

Place these events in the correct order:

  1. Phagocytes arrive
  2. Mast cells release histamine
  3. Blood vessels dilate
  4. Pathogens enter through damaged tissue

4 → 2 → 3 → 1

500

Explain why antibodies are generally ineffective against viruses that are already inside host cells.

Antibodies cannot enter infected cells, so intracellular pathogens must be eliminated by cytotoxic T cells

500

Explain the difference between active and passive immunity.

Active immunity occurs when an individual's immune system produces its own antibodies and memory cells, whereas passive immunity occurs when ready-made antibodies are received from another source and no memory cells are formed

500

A student cuts their finger while gardening. Describe the sequence of immune responses from the initial barrier breach until antibody production.

  • Physical barrier is broken.
  • Pathogens enter tissue.
  • Mast cells release histamine.
  • Blood vessels dilate and become more permeable.
  • Neutrophils and macrophages arrive and phagocytose pathogens.
  • Dendritic cells present antigens.
  • Helper T cells are activated.
  • B cells are activated.
  • Plasma cells produce specific antibodies.
  • Memory B and T cells are formed.
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