intracellular accumulations
triglycerides
Abyssinian cats are known for this type of amyloidosis
hereditary renal amyloidosis
this type of pathologic calcification has normal blood calcium levels while this type has deranged systemic calcium metabolism respectively.
what is dystrophic and metastatic?
what statement best defines cardiac hypertrophy?
an increase in the size of individual cardiomyocytes
what dog breed is genetically predisposed to familial amyloidosis?
describe 2-3 forms of protein accumulation and in which types of cells they are seen in
Mallory bodies- in hepatocytes
renal casts- tubular casts in proteinuria
Russell bodies- plasma cells
corpora amylacea- prostate or brain
Dutcher bodies- indents the nucleus
a chicken with vitamin A deficiency develops squamous metaplasia in kidneys. what is the resulting condition?
renal gout
describe the mechanism of hyperparathyroidism acting as a cause of metastatic calcification.
excessive secretion of PTH increases calcium levels
a highly conditioned thoroughbred has an enlarged heart on echo but has normal cardiac function and no clinical signs. what is the most likely explanation?
(hint: Daejon Love/ sports)
physiologic athletic remodeling
which special stain is classically used to confirm presence of amyloid?
congo red
in a PAS-stained liver section of a dog on steroids, hepatocytes appear magenta and vacuolated. what is the most likely stored substance?
glycogen
secondary amyloidosis
Von Kossa stain causes this color of the granular deposits while Alzarin stain causes.
black
red
a 9 y/o spayed female DSH with a BCS of 8/9 is presented for an 8-day history of anorexia, vomiting, lethargy, and weight loss. physical exam reveals dehydration, icterus, and hepatomegaly. what is the condition?
feline hepatic lipidosis
amyloid deposits demonstrate which characteristic appearance with congo red staining under polarized light?
green birefringence
a salivary cyst in a dog is filled with pale blue mucin and lined by vacuolated epithelium. what is the diagnosis?
salivary mucocele
This type of amyloid is derived from Serum Amyloid A (SAA) during chronic inflammation
What is AA (Amyloid A) Amyloidosis?" (Also accepted: Secondary or Reactive Amyloidosis)
name 1 out of the 3 sites of occurrence of dystrophic calcification
necrotic tissue
heart valves
tuberculosis
a cat with suspected hepatic lipidosis is dehydrated, hypokalemic, nauseous, and has not eaten for 7 days. after initial stabilization and control of nausea, which intervention is most important?
enteral nutritional support
a group of sheep develops sudden weakness, icterus, hemoglobinuria, and severe anemia shortly after a stressful event. what mechanism explains these findings?
sudden hepatic copper release causing oxidative destruction of RBC
this condition in cattle is related to fatty change/ lipid accumulation
ketosis
extracellular hyalinosis is composed of collagen and ________ and _________
plasma proteins and basement membrane material
this form of intrinsic cause of cellular aging triggers reduced mitotic potential; while this extrinsic cause institutes the damage of proteins, lipids, and nucleic acids
telomere shortening and oxidative stress (free radicals)
a 7 y/o dog presents with lethargy, weight loss, polyuria, and polydipsia. urinalysis reveals 3+ proteinuria. serum albumin is decreased and cholesterol is markedly increased. which renal lesion is most likely responsible?
glomerular amyloid deposition
A flock of sheep has experienced several cases of chronic copper toxicosis despite receiving a diet that contains copper concentrations in an acceptable range. analysis of the diet reveals an increased copper-to-molybdenum ratio. what best explains why this flock remains at an increased risk factor for copper toxicosis?
low molybdenum reduces copper antagonism. allowing increased copper absorption and hepatic accumulation