EBV
Classic triad of infectious mononucleosis.
What is fever, sore throat, and posterior cervical lymphadenopathy?
Key lab feature distinguishing CMV mono from EBV mono.
What is a negative Monospot (heterophile-negative)?
High-risk US animals are responsible for most human rabies cases.
What are bats (also raccoons, skunks, foxes)?
Primary route of transmission.
What is fecal–oral transmission?
Classic triad of Creutzfeldt-Jakob disease.
What is rapidly progressive dementia, myoclonus, and ataxia?
Receptor EBV uses to infect B lymphocytes.
What is CD21?
Characteristic histologic finding on tissue biopsy.
What are owl-eye inclusion bodies?
Painful throat spasms when trying to drink water.
What is hydrophobia?
Type of paralysis classically seen in paralytic polio.
What is asymmetric flaccid paralysis?
Nature of the infectious agent.
What is a misfolded protein with no DNA or RNA?
Reason amoxicillin causes a rash in EBV patients.
What is a non-allergic maculopapular “ampicillin rash” from immune interaction?
Most common congenital CMV sequela.
What is sensorineural hearing loss?
Mechanism of viral spread from bite site to brain.
What is retrograde axonal transport along peripheral nerves?
Spinal cord structure destroyed by poliovirus.
What are anterior horn cells?
Highly specific CSF test for prions.
What is RT-QuIC?
Blood smear finding representing activated cytotoxic T cells.
What are atypical lymphocytes?
Fundoscopic appearance of CMV retinitis in AIDS patients.
What is the “pizza pie” retina (hemorrhages with white exudates)?
Immediate management after bat exposure even without visible bite.
What is post-exposure prophylaxis with RIG plus rabies vaccine?
Key feature distinguishing polio from Guillain-Barré.
What is preserved sensation with asymmetric weakness?
Expected outcome despite treatment.
What is uniformly fatal within about 1 year?
Life-threatening complication requiring avoidance of contact sports for ~1 month.
What is splenic rupture?
First-line antiviral for severe CMV in immunocompromised patients.
What is ganciclovir (or valganciclovir)?
Prognosis once neurological symptoms develop.
What is nearly 100% fatal?
Historical device used to support breathing in bulbar polio.
What is the iron lung?
Characteristic MRI finding.
What is cortical ribboning with basal ganglia hyperintensity?