Name the CD markers
These CD markers are present in a normal resting B lymphocyte (6)
CD19, CD20, CD22, Kappa light chain, lambda light chain, CD79a
Positive for CD19, CD20, CD5, CD23
Chronic lymphocytic leukemia
Includes the following disease states: primary myelofibrosis, chronic myeloid leukemia, essential thrombocythemia, polycythemia vera
myeloproliferative neoplasms (MPNs)
Classification of AML according to the WHO requires this percentage of cells to be blasts
20%
This is the most common form of childhood leukemia
Acute lymphoblastic leukemia
These CD markers are present on a T lymphocyte (6)
CD2, CD3, CD4, CD5, CD7, CD8
Positive for CD19, CD22, CD10, CD34, CD117, & TdT
Acute lymphoblastic leukemia
Includes the following disease states: pelger-huet, may hegglin, alder reilly, chediak higashi
Non-malignant, qualitative
AML is most common leukemia in which population?
adults
Polycythemia vera, essential thrombocythemia, and primary myelofibrosis could occur due to this mutation.
JAK2 mutation
These CD markers are present on blasts (2)
CD34 & CD117
Positive for CD38
Plasma cell disorders - multiple myeloma, plasma cell leukemias
Includes neutrophilia, neutropenia, eosinophilia, monocytosis, etc
Non-malignant; quantitative
AML M5 would demonstrate a proliferation of which types of cells?
granulocytes & monocytes
Hodgkin lymphoma is characterized by the presence of these cells
Reed-Sternberg cells
These CD markers are present on granulocytes/monocytes (4)
CD13, CD14, CD15, CD33
Positive for CD14
A monocyte leukemia, such as AML M5
Includes acute myeloid leukemia, acute lymphoblastic leukemia (t-cell & b-cell)
acute leukemias
Auer rods are usually present in which type of cell?
myeloblasts (occasionally promyelocytes)
This nonmalignant, qualitative disorder can be characterized by giant platelets and Dohle body-like inclusions
May Hegglin anomaly
These CD markers are present on megakaryocytes (3)
CD41, CD42, CD61
Positive for CD13, CD15, CD33
Granulocytic conditions, such as AML & MDS
Includes chronic lymphocytic leukemia, hairy cell leukemia, burkitt lymphoma, sezary syndrome, hodgkin lymphoma, etc.
mature lymphoid neoplasms (MLN)
acute promyelocytic leukemia is associated with which cytogenic translocation?
t(15;17) PML/RARA
Myelodysplastic syndrome can demonstrate dyspoiesis in which cell lines?
Dyserythropoiesis
Dysmyelopoiesis
Dysmegakaryopoiesis