Oh my aching muscles
Pain all over, feeling exhausted, poor quality sleep, no weakness with motor testing
What is Fibromyalgia
Condition resulting in granulomatous inflammation of the internal elastic membrane and infiltration of CD4+ T cells and macrophages.
What is Giant Cell Arteritis
Type of inflammatory cells found to infiltrate salivary and lacrimal glands in patient with Sjogren’s syndrome
What are CD4+ lymphocytes
Common test used to evaluate fracture risk
What is Dual Energy Xray Absorptiometry DXA
The reason why calcineurin inhibitor (cyclosporin, voclosporin) levels are affected by grapefruit juice.
What is metabolism by CYP3A4
Name for the violaceous plaques over knuckles associated with Dermatomyositis
What are Gottren’s papules
Elderly female patient presenting with a systemic condition with symptoms of proximal hip and shoulder girdle stiffness, elevated CRP, ESR. No headache or jaw claudication.
What is polymyalgia rheumatica
Two antibodies found associated with Sjogren’s Syndrome.
What are anti Ro (ssA) and anti La (ssB) antibodies
Effect of increased RANK ligand on bone density
What is stimulation of Osteoclast recruitment/differentiation and activity
Class of drugs which includes baricitinib, tofacitinib, and upadacitinib
What are Janus Kinase inhibitors
The patient has progressive proximal muscle weakness after taking a statin. What is the antibody associated with this medication toxicity
What is HMG CoA reductase antibody
Name 2 cytokines which are found elevated in giant cell arteritis and polymyalgia rheumatica
What are IL6 and TNF alpha
Systemic condition associated with antibody “DNA topoisomerase I”.
What is systemic sclerosis
Condition of bone under mineralization related to vitamin D deficiency
What is Rickets or Osteomalacia
What conventional synthetic DMARD has it’s mechanism of action by inhibiting amino-imidazole-carboxamide-ribonucleotide (AICAR) transformylase and thymidylate synthetase leading to extracellular AMP accumulation, inhibiting inflammation, suppressing neutrophil, macrophage, dendritic cell, and lymphocyte function.
What is methotrexate
Type of myositis which is more common in adults over 65 years old and associated with slow progressive weakness, dysphagia, and only modest elevation in CPK
What is Inclusion Body Myositis
Granulomatous vasculitis occurring in individuals under age 50 yearswith pathologic findings of transmural thickening of the aorta, particularly the aortic arch and great vessels and resulting in severe luminal narrowing and possibly loss of peripheral pulses.
What is Takayasu’s arteritis
Antibody type resulting in ‘biologic false positive RPR'.
What is antiphospholipid antibody
Metabolic condition responsible for bone loss (osteoporosis) involving the phalanges
What is hyperparathyroidism
Biologic agent which is a chimeric monoclonal antibody (bDMARD) that targets CD20 B-lymphocytes and is indicated for the treatment of Adult Rheumatoid Arthritis
What is Rituximab
Distinct skin biopsy findings of depositions in the capillary beds which contributes to the skin rashes associated with dermatomyositis.
What is C5b-9
Type of vasculitis that has been associated with aneurysms and chronic Hep BsAg
What is polyarteritis nodosa
Type of hypersensitivity occuring in Lupus Nephritis
What is type III hypersensitivity
Metabolic bone disorder characterized by increased but disordered and structurally unsound bone mass
What is Paget’s disease of bone
Biologic agent with novel mechanism of inhibition of T-cell activation by binding to ligands CD80 and CD86 on antigen-presenting cells (APCs), ultimately blocking CD80 and CD86 interaction with CD28 on T cells.
What is Abatacept