Humoral Immunity
Humoral immune responses are our defense against what kind of pathogens and toxins?
What are extracellular pathogens?
Cell mediated immunity relies on what cells at the effector phase rather than antibodies?
What are T-cells?
A characteristic of high grade malignancies that refers to an irreversible loss of cellular differentiation.
What is anaplasia?
This process turns harmless, microscopic clusters of dormant tumor cells into overt metastases
What is angiogenesis?
Bleomycin and Busulfan can cause this toxicity
What is pulmonary fibrosis?
This antibody is particularly important for the opsonization of encapsulated organisms
What is IgG?
T cell activation requires binding of?
What is B7 (APC) and CD28 (T cell)
This tissue change is characterized by an increase in number while tissue REMAINS ORGANIZED!!!!
What is hyperplasia?
Benign neoplasm typically have this suffix
What is -oma?
Hemorrhagic cystitis is a toxicity associated with this drug
What is cyclophosphamide?
Antibody-dependent cell-mediated cytotoxicity is used when pathogens are too large to be phagocytosed in what kind of infections?
Bonus: What antibody is important for ADCC?
What are parasitic/helminth infections?
Bonus: What is IgE?
In what lymphoid organ to APCs activate CD4+ or CD8+ T cells?
Tissue change where one normal cell type is replaced by another normal cell type
What is metaplasia?
Neoplasms with glandular epithelial origin are called
What are adenomas?
nephrotoxicity and ototoxicity are common in these 2 drugs
What are cisplatin and carboplatin?
Fill in the blanks:
T cell independent responses are _____ and ____ allow for memory formation.
T cell dependent responses are ______ and _____ allow for memory formation.
T cell independent responses are quick and do not allow for memory formation.
T cell dependent responses are slow and do allow for memory formation.
An infected dendritic cell will activate what kind of cell?
vs
A dendritic cell that has phagocytosed a pathogen will activate what kind of cell?
What are CD8+ cytotoxic T cells?
vs
What are Th1 cells?
This hard - I make worth 500 :)
What is the hallmark of a carcinoma in situ?
What is malignancy without invasion of basement membrane?
Tumors with mesenchymal origin have this suffix
What is -sarcoma?
what toxicity is associated with vincristine?
What is peripheral neuropathy?
Activation of B cells in T dependent reposes requires binding of?
What is CD40 and CD40L?
This process allows exogenous (phagocytosed) antigens to be presented to CD8+ T cells on MCH class 1.
What is cross presentation?
pls don't ask questions ab this or I will cry
Tumor ___ characterized malignancy while tumor ___ characterizes tumor size and extension.
What is grade?
What is stage?
tumors with non-glandular epithelial origin are called?
What is carcinoma?
What three drugs are associated with cardiotoxicity?
What are doxorubicin, daunorubicin, and trastuzumab?