Embryology
Fertilization most commonly occurs in this part of the fallopian tube
What is the ampulla?
The endometrium is primarily lined by this type of epithelium.
What is simple columnar epithelium?
This enzyme deficiency causes Von Gierke's disease (Type I GSD).
What is glucose-6-phosphatase?
This process results in two diploid daughter cells identical to the parent cell.
What is mitosis?
Ceftriaxone belongs to this class of antibiotics.
What are third-generation cephalosporins?
By day 3-4 post-fertilization, the zygote becomes this solid 16-cell structure.
What is the morula?
The spleen's white pulp is mainly responsible for this function.
What is the adaptive immune response to bloodborne antigens?
This enzyme deficiency leads to Pompe disease, causing glycogen buildup in lysosomes.
What is lysosomal α-1,4-glucosidase?
The Philadelphia chromosome results in _______ between chromosomes 9 and 22.
What is a translocation?
Methotrexate inhibits this enzyme, blocking DNA synthesis.
What is dihydrofolate reductase?
This hormone, secreted by the syncytiotrophoblast, maintains the corpus luteum in early pregnancy
These macrophage-filled cords are found in the spleen's red pulp
What are the splenic cords (of Billroth)?
In hereditary fructose intolerance, deficiency of this enzyme leads to toxic accumulation of fructose-1-phosphate.
What is aldolase B?
The BCR-ABL fusion protein activates this signaling pathway, among others, leading to uncontrolled growth.
What is the JAK/STAT pathway?
Imatinib and dasatinib are drugs that target this abnormal tyrosine kinase in CML.
What is BCR-ABL?
This shunt connects the pulmonary artery to the aorta in fetal circulation, bypassing the lungs.
What is ductus arteriosis?
The anterior pituitary (adenohypophysis) is derived from this embryologic structure.
What is Rathke's pouch? (oral ectoderm)
Lactic acidosis in Von Gierke’s disease occurs because this energy-producing cycle is disrupted.
What is the Cori cycle? OR What is gluconeogenesis?
This growth factor from the liver mediates the effects of GH on bone and muscle growth.
What is IGF-1?
Compared to first-generation TKIs, second-generation TKIs achieve faster and deeper responses in this leukemia.
What is CML (chronic myelogenous leukemia)?
What is the male version of theca cells in a female?
Theca cells
These contractile stromal cells of the spleen help expel stored RBCs during hemorrhage.
What are myofibroblasts?
Anderson’s disease (Type IV glycogen storage disease) is due to deficiency of this enzyme, producing amylopectin-like glycogen.
What is the branching enzyme (glycosyl 4:6 transferase)?
Laron syndrome results from mutations in this receptor, leading to short stature despite normal GH.
What is the GH receptor?
Dasatinib toxicity may cause this pleural complication, requiring monitoring and possible dose adjustment.
What is a pleural effusion?