Background
What physiological condition is suggested to be present in the prefrontal cortex (PFC) of schizophrenia patients?
What is physiological hypoactivity?
What type of study design was used in this research?
What is a double-blind placebo-controlled study?
What was the overall effect of amphetamine on rCBF during the BAR control task?
How did amphetamine affect blood flow in the brain during the BAR control task?
What is a small, not statistically significant decrease?
What ethical principle requires participants to give informed consent before joining the study?
What is informed consent?
How might the findings of this study affect treatment approaches for schizophrenia?
What is by suggesting that dopaminergic agonists could enhance cognitive function?
Who observed a negative correlation between central dopaminergic hypoactivity and PFC activation in Parkinson’s patients?
Who is Weinberger et al.?
How many participants were involved in the study?
What is ten?
Did amphetamine levels correlate significantly with cognitive change scores on the WCST?
What is no?
Why is it important to stabilise participants on haloperidol before administering amphetamine?
What is to prevent exacerbation of psychotic symptoms?
What does the study imply about the role of dopamine in cognitive tasks for schizophrenic patients?
What is that dopamine may help improve task performance?
What neurotransmitter is primarily associated with enhancing 'signal to noise' in the brain?
What is dopamine?
Which medication were participants stabilized on prior to the study?
What is haloperidol?
What two parameters of performance on the WCST improved with amphetamine?
What are the number of correct responses and percent conceptual level responses?
What rights must be explained to participants prior to the study?
What are the rights to withdraw and to anonymity?
What future research could be suggested based on this study's findings?
What is investigating other dopaminergic treatments for cognitive deficits in schizophrenia?
What cognitive task was used to assess PFC function in this study?
What is the Wisconsin Card Sort Test (WCST)?
What imaging technique was used to measure regional cerebral blood flow (rCBF)?
What is Xe Dynamic Single-Photon Emission Computed Tomography (SPECT)?
Which area of the brain showed significant activation during the WCST when participants were on amphetamine?
What is the dorsolateral prefrontal cortex (DLPFC)?
What potential harm must researchers disclose to participants regarding the study?
What is the risk of stress due to genetic testing results?
How could these findings influence the understanding of 'hypofrontality' in schizophrenia?
What is by providing evidence that it may be reversible with treatment?
What is the hypothesis regarding dextroamphetamine's effect on DLPFC activation during cognitive tasks?
What is it will increase DLPFC activation?
How long were participants assessed daily before participating in the study?
What is two weeks?
What does the study suggest about the relationship between amphetamine and PFC function in schizophrenia?
What is it may enhance task-specific activation?
How does the study address the issue of participants being too ill to provide informed consent?
What is by ensuring they are stabilised and able to cooperate with procedures?
What broader impact could this study have on mental health treatment and policy?
What is promoting research into pharmacological interventions for cognitive impairments in mental health disorders?