When both central and peripheral tolerance break down.
What is development of autoimmunity
100
2 classifications of autoimmune disease
What is mediated by self-antibody or self-reactive
100
Harmful immune reactions produced by normal immune system that cause tissue injury and may cause serious disease
Hint: requires pre-sensitized state of the host
What is a hypersensitivity reaction
100
Sensitization, Immediate hypersensitivity, and late phase reaction.
What are 3 Steps of the IgE-mediated Allergic Response
100
A transplant where the donor is the recipient
Ex: skin graft
What is autologous graft
200
The way Eric plans to control the "stupid question" problem in class.
Initial exposure to allergen leads to production of allergen specific IgE
What is sensitization
200
A transplant between two individuals in the same species
What is an allogeneic graft
300
Selection of T cells able to see self MCH
Hint: happens in the thymus
What is positive selection
300
When T cells specific for self-antigens become
activated
What is cell-mediated autoimmunity
Note: classic examples are type 1 diabetes, rheumatoid arthritis and multiple sclerosis.
300
IgG or IgM mediated cytotoxic hypersensitivity, cell destruction via complement activation
Hint: Hemolytic Disease of the Newborn
What is Type II
300
Occurs within minutes of subsequent exposure of the IgE antibody to the allergen
Note: Reflects release of mediators such as histamine
What is immediate hypersensitivity
300
A transplant between two individuals of two different species
Ex: pig heart valve
What is xenogeneteic graft
400
Deletion of those T cells with a high affinity for self-peptide-MHC complexes that are thus autoreactive
What is Negative selection
400
When an antibody that recognizes a self protein and binds the complement can be brought in and the inflammatory response develops
Hint: autoimmune hemolytic anemia
What is antibody mediated
400
Immune complex responses that are directed against soluble antigens and tissue damage.
What is Type III
400
Occurs within hours to days of exposure. Reflects influx of inflammatory cells (eosinophils and Th2 lymphocytes)
What is a late phase reaction
400
When the donor tissue attacks the host
Hint: most common in bone marrow transplants
What is graft versus host
500
Prevents the activation of self-reactive T cells and
B cells.
Note: Multiple different pathways this is accomplished.
What is peripheral tolerance
500
Tacoma's favorite Seattlite
Hint: rhymes with Eeyore
Who is Leore
500
Cell mediated hypersensitivity
What is Type IV
500
If Aimee tries to sneak cashews in class our classmate will have this type of hypersensitivity reaction.