Wound Healing

Tell methe cell

100

1st cell to arrive to the wound, responsible for sterilization of wound bed

Neutrophils

200

Cell responsible for secretion of chemotactic agents and growth factors necessary for wound healing

Macrophages

300

Cell involved in epithelialization of the wound

Keratinocytes

400

Key cell involved in proliferative phase of wound healing

Fibroblasts

500

Cell involved in wound contraction and wound healing by secondary intention

Myofibroblast

Oh no

100

Large amount of pink or salmon colored fluid from the wound

Dehiscence

200

3 most common sites of pressure ulcers

Sacrum

Ischium

Greater trochanter

300

Prevention or early treatment of keloids

Lidocaine + triamcinolone acetonide injection

400

Genetic conditions associated with abnormal wound healing

1- Osteogenesis imperfecta

2- Ehler Danlos

3- Marfan's

500

5 Contraindications for primary wound closure

1- Grossly contaminated with debris that cant be completely removed

2- Infected tissue

3- Late, noncosmetic wounds

4- Animal/human bites

5- Deep puncture wounds

6- High tension wounds

7- Actively bleeding wounds

Healing

100

Type of collagen laid down during the final stage of wound healing

Type 1

200

2 Essentials of wound healing

1- Moist environment

2- Sufficient oxygen delivery

3- Avoid local edema

4- Removal of necrotic tissue

300

For a primarily closed wound, healing is complete by ___ weeks with tensile strength of ___% of normal tissue

6-8 weeks

75-80%

400

Name the 4 stages of wound healing

1- Hemostasis

2- Inflammation

3- Proliferative

4- Maturation/Remodeling

500

2 conditions for which there is evidence for use of hyperbaric oxygen therapy

1- Radiation induced wounds

2- Chronic diabetic wounds

Grafts and flaps

100

Clinical indication for readiness of skin graft

Presence of healthy granulation tissue

200

Feature of split thickness grafts that is greater than in full thickness grafts

Secondary contracture

400

3 Reasons for graft failure

1) Hematoma

2) Infection

3) Seroma

4) Shear forces

5) Technical error

500

3 Indications for flaps

1- Extremity trauma

2- Oncologic reconstruction

3- Irradiated wounds

4- Wounds with exposed bone or other deep structures

5- Chronic wounds that failed conservative management

Miscellaneous

100

Trace metals involved in normal wound healing (2)

Zinc & Copper

200

Mechanism by which scurvy inhibits wound healing

Decreased hydroxylation or lysine and proline, resulting in decreased collagen production

300

Supplement that can aid in wound healing specifically in patients on chronic steroid therapy

Vitamin A

25,000 IU

400

Mechanism by which negative pressure wound therapy aids in wound healing

1- Increases blood flow to site

2- Decreases local edema