Class
What is NDRI (norepinephrine/dopamine receptor inhibitor)?
NDRIs prevent reuptake of dopamine and norepinephrine, which creates a higher concentration allowing for more of these to be activated.
What are receptors?
This is the Black Box Warning carried by NDRIs.
What is increased suicidal ideation under age 25?
The NP should follow this dosing ideology when first starting a patient on Bupropion (Wellbutrin) .
What is start low and go slow?
This level of Bupropion (Wellbutrin) is <10%, meaning it has a low threshold but does pass through breast milk.
What is relative infant dose (RID)?
Bupropion (Wellbutrin) is FDA approved to treat these conditions.
What are seasonal affective disorder (SAD), depression, and smoking cessation?
These two transporters are blocked by NDRIs.
What are Norepinephrine Transporter (NET) and Dopamine Transporter (DAT)?
Bupropion (Wellbutrin) should be avoided in these groups of persons who may be at risk of seizures.
Who are persons with seizure history, alcohol withdrawal, traumatic brain injury, or eating disorders?
Bupropion (Wellbutrin) dosing may need to be adjusted in patients with these impairments.
This group of patients need to be more closely monitored when prescribed Bupropion (Wellbutrin).
Who are the elderly?
Bupropion (Wellbutrin) is used off label for these conditions.
What is ADHD in pediatrics and adults?
Bupropion (Wellbutrin) has little impact on this commonly targeted monoamine/neurotransmitter.
What is serotonin?
Bupropion (Wellbutrin) is this class of pregnancy drug.
What is Category C?
This cannot be measured, so it is important to monitor patients for clinical signs of improvement or side effects.
What is serum Bupropion (Wellbutrin) level.
Two potential food interactions with Bupropion (Wellbutrin) include this and this as the former may increase seizure risk, and the latter may increase insomnia or jitteriness.
What are alcohol and caffeine?
This monoamine is responsible for the "fight or flight" response, originates in the Locus Coeruleus, is responsible for alertness, focus and stress response, and is also implicated in MDD, ADHD.
What is norepinephrine?
Because Bupropion (Wellbutrin) targets neurotransmitters, it may take this long to notice symptom improvement.
What is 2-4 weeks?
These include tremors, blurry vision, headache, weight loss, constipation, insomnia, dizziness and tachycardia.
What are side effects?
Baseline laboratory such as these need to be monitored to rule out any contributing medical disease, along with regular blood pressure and weight.
What are TSH, CBC, BMP, UA, Vitamin D labs?
3 important red flag side effects to watch for when prescribing Bupropion (Wellbutrin) include these.
Increased suicidal ideation, dysrhythmias, and tremors.
This monoamine originates in the Substantia Nigra and Ventral Tegmental Areas of the brain, is responsible for reward, pleasure, attention and motivation, and is implicated in psychosis, schizophrenia and bipolar disorders.
What is dopamine?
Bupropion (Wellbutrin) is available in these two prescription versions of oral tablets that can be taken either once a day or 2-3 times per day.
What are immediate and sustained release?
Bupropion (Wellbutrin) has a drug-drug interaction with MAOIs as it can increase the risk for this.
What is hypertensive crisis?
This is especially important when prescribing Bupropion (Wellbutrin) to your patients and is vital to shared-decision making and informed patient decision making.
What is education?
Bupropion (Wellbutrin) is metabolized by this CYP 450 enzyme which is also responsible for metabolizing opioids, other antidepressants, and some antiretrovirals.