Numbers
The maximum dose of Zembrace that may be given in 24 hours
12mg
After this type of test, the Zembrace PI states that patients should have their first dose administered in a medically supervised setting.
A negative cardiovascular evaluation and have multiple risk factors for CAD
These are the 4 drugs that are especially important to tell your provider about before taking Zembrace
The object that is consealed by the Symtouch for Zembrace.
29 gauge needle
The temperature at which Zembrace should be stored
Store between 68° to 77°F (20° to 25°C)
The length of needle penetration into the skin during the delivery of Zembrace.
1/4 inch
The two locations approved for Zembrace to be injected.
Arm and Thigh
The amount of time a patient should wait before redosing Zembrace
One hour....
3 mg per dose each dose separated by one hour for a max of 12 mg
Although patients may prefer sumatriptan tablets, the injectable form can be used as a fast acting option for migraine pain relief. However, patients need to wait this amount of time after a sumatriptan tablet to administer Zembrace
1 hour
Section 2.1 of the PI
In the dose dependent study 1 of the PI, these 6 dosage forms have results at 10 min, 30 min, 1h hr and 2 hours
1, 2, 3, 4, 6, 8
In a dose range study, published in the Zembrace PI, this is the amount of time 17% of patients experienced pain relief, after a one dose of Zembrace
10 minutes
The 4 supplies needed to deliver the Zembrace injection
Autoinjector, alcohol swab, sterile cotton ball or gauze and Puncture-resistant Sharps container
These are common AE's for Zembrace
injection site reactions, tingling, dizziness/vertigo, warm/hot sensation, burning sensation, feeling of heaviness, pressure sensation, flushing, feeling of tightness, and numbness/ paresthesia. (6.1)
This is the half-life of Zembrace
terminal half life is 115 ± 19 minutes
This is the chemical structure of Sumatriptan
Selective agonist for a vascular 5-HT1 receptor
This percentage represents the amount of people that found migraine pain relief 2 hours after an injection of Zembrace in our dose range study.
60%
The items that are inside one carton of Zembrace
4 units, PI, Instructions for Use
This is a term/phrase used for prescribing in a situation like this: A prescriber writes Zembrace for a 62 year old, with no history of stroke or heart disease and it successfully provides relief of their cluster headache
What is prescribing off label
Warnings on the Zembrace label include all of the following but one:
Chest/Throat tightness, Neurofibromatosis, Arrhythmias, Myocardial ischemia/infraction
Neurofibromatosis
Zembrace may cause Raynaud's syndrome which is known to cause this symptom
Changes in color or sensation in your fingers and toes
The total number of patients, in a study of 111, that reported 12 AE's in and double -blind study of Zembrace.
8
A total of 8 patients reported 12 events. More than 90% of paitents reported NO Triptan-related AE's
This is the amount of time that Zembrace takes to reach peak concentration (Tmax)
12 min
This condidiotn is caused by overuse of acute migraine drugs (10 or more days).
Medication Overuse Headache
This Zembrace contraindication can cause rapid heart rate and was named after Louis Wolff, John Parkinson, and Paul Dudley White who described the ECG findings in 1930.
Wolf-Parkinson-White syndrome
This is the NDC # of one auto injector of Zembrace
0245-0809-89
0245 is Upsher-Smith
0809 is the Drug code for that manufacturer
89 is the package form, 3mg autoinjector (or dosage of the med)