Epidemiology/Testing
The three tumor types that comprise GEA
What are...
Esophageal adenocarcinoma
GEJ adenocarcinoma
Gastric adenocarcinoma?
At 5'9, 150 pounds (68.04kg), this would be my Q3W dose of Ziihera
True or False?
26.4 months of overall survival was realized in arm B of the HORIZON-GEA-01 trial
What is false? Arm C (zani/ct/tisle)
A 4mg twice-daily premedication of loperamide should start on day 1 of cycle 1 for at least this many days.
What is 7 days?
This American attorney and businessman best known for his defense of OJ Simpson, passed away from esophageal cancer in 2003
Who is Robert Kardashian?
This percent of GEA pts have HER2 overexpression
What is ~20%?
At 6'3, 205lbs (93kg), this would be my Q2W dose of Ziihera
What is 1,600mg?
Duration of response realized in arm C of the HORIZON-GEA-01 trial (months)
Most cases of diarrhea occurred early and typically resolved within this many weeks
What is three weeks?
This legendary Hollywood actor, who passed away from esophageal cancer in 1957, claimed in 1942 that 'We'll always have Paris'
Who is Humphrey Bogart?
A type of tissue-based assay test that detects protein expression on the surface of cells
What is IHC?
120 minutes
What is the first recommended infusion duration of Ziihera?
Of the three arms included in the HORIZON trial this arm boasted the highest complete response rate, at 20%
What is Arm C?
Percent of grade 3 or higher diarrhea experienced in Arm C of the HORIZON-GEA-01 trial
What is 25%?
This 70's and 80's rocker received HIS 'Two Tickets To Paradise' when he passed away in 2019 from esophageal cancer
Who is Eddie Money?
The 5-year survival of GEA pts with distant disease at diagnosis
What is <10%?
An infusion related reaction was reported in this percent of 330 pts treated with Zani/CT/Tisle
What is 22%?
Of the 914 pts randomized into HORIZON-GEA-01, 195 pts had GEJ, 81 pts had esophageal adenocarcinoma, and this many had gastric adenocarcinoma
What is 638?
Grade 3 diarrhea is defined by an increase of this many stools per day
What is at least 7?
This country music star, who passed away from stomach and GEJ cancer in 2024, had twenty #1 hits on Billboard's Hot Country Songs chart between 1993 and 2011
Who is Toby Keith?
32% is the rate of HER2 overexpression/amplification in this GEA tumor location, the highest rate of the three.
What is GEJ cancer?
Zanidatamab is a bispecific antibody that binds to these two extracellular domains
What are ECD2 and ECD4?
This arm of the HORIZON trial realized the highest median in months of Progression Free Survival at 14.2
What is Arm B (zani/ct)?
4% and 1.6%
What are the discontinuation rates for diarrhea in Arms C and B, respectively?
This legendary television host, who famously introduced the Beatles to America in 1964, passed away in 1974 of esophageal cancer, which was diagnosed only weeks before his death.
Who is Ed Sullivan?