Acronyms
One single order form to replace all current forms - UTRF
What is Universal TRF?
The "shell" case generated for the next timepoint due.
What is Monitoring Repeat Order?
Upon reporting (assuming criteria met), a subsequent Reveal MRD request is automatically created unless this is selected.
What is one-time order?
Therapy Response Monitoring is not one of these.
What is a one time test?
These are the 3 monitoring programs available on the UTRF.
What are MRD + Monitoring, Complete Profiling + Monitoring, and Liquid Profiling + Monitoring?
The proportion of circulating tumor DNA present within the total amount of cell-free DNA circulating in a patient's blood - TF
What is tumor fraction?
This case will generate if a TRM or Cascade order does not have an aliquot available for testing.
What is Order Ready for Sample?
This is the number of weeks after surgery/therapy that a patient is eligible for a Post-Surgery Program order.
What is 3-13 weeks?
This is the Guardant standard cadence for TRM.
What is every 3 months?
This is generated as a notice to the client for a new blood draw, but does not need to be returned (can be returned with a sample).
What is a confirmatory TRF (no signature required)?
Reveal indicated for early stage cancer for recurrence monitoring - MRD
What is minimal/molecular residual disease?
The case that generates if a patient had a previous MRD order and the office is attempting to enroll the patient in a new Post-Surgery program
What is Verify Post Surgery Eligibility?
Assuming "opt out" has not been selected, this is what is triggered when Reveal MRD results positive with a tumor fraction ≥0.05%, and a patient has not had a Guardant360 Liquid test in the last 45 days
What is molecular recurrence cascade?
Reveal TRM will report these three things.
What are ctDNA detected/not detected, tumor fraction, and molecular tumor type?
This is required when either a "PLASMA HOLD: Therapy Confirmation/Signature" or a "PLASMA HOLD: Pending Order Confirmation" PC is generated.
What is a confirmatory TRF (signature required)?
Reveal indicated for advanced stage cancer to evaluate therapy response - TRM
What is therapy response monitoring?
On a Therapy Response Monitoring program, this case will generate 2 weeks after the CDx or G360 Liquid report releases
What is PLASMA HOLD: Pending Therapy Confirmation/Signature?
This is the guideline-based, blood draw cadence for patients diagnosed with CRC enrolling into the Surveillance Program.
What is every 3 months for 2 years post-surgery/therapy, then every 6 months?
On a Therapy Response Monitoring program, this case will generate when there is a molecular progression TF increase of >50%.
What is PLASMA HOLD: Pending Order Confirmation?
For monitoring program orders, this is the default blood draw management preference if nothing is selected.
What is first draw completed in-office; subsequent draws managed by Guardant phlebotomy services?
Molecular testing that analyzes a range of genes in a tumor sample - CGP
What is comprehensive genomic profiling?
This case will generate if a patient has an existing TRM program order in initial status, but the client submits an additional order for the same patient.
What is PLASMA HOLD: Existing Testing Program?
This is the total, self-pay cost of a completed Post-Surgery Program order.
What is $10,500?
These are the three required fields when completing a cTRF for PLASMA HOLD: Pending Therapy Confirmation/Signature.
What are therapy initiation date, therapy class, and signature?
These are the three options a client can choose when completing a cTRF for PLASMA HOLD: Pending Order Confirmation.
What are run G360 Liquid + cont. TRM, cont. TRM only, or void request?