Nanotechnology
Drug release is prolonged because of lower surface/volume ratio and lower surface area exposure to the biological fluids
What are microparticles?
What is to allow maximum absorption of each drop
Purpose of 5 Minute intervals and breath-holding
What is maximum deposition into lungs
___ Ensures the tablet remains intact after compression and improves free-flowing qualities by formulation of granules
what are binders?
Diameter d of a sphere that occupies the same volume (volume-weighted diameter) as irregularly shaped particle
What is a definition of particle size?
Brownian (random) movement causes these particles to collide more times
What are nanoparticles?
Optimal Ophthalmic Drug Volume
Filling that loses propellant and has moisture contamination
What is cold-filling?
____ Prevents adhesion of table to surface and improves flowability
What is a lubricant?
Sugar is a _____ particle
What is polydisperse particle
The property of antibodies that allows long circulation or low clearance.
What is the glomerular filtration cutoff size and hydrophilic nature of the surface?
Pathways or tissues that allow entry of a drug into systemic circulation.
What is:
Nasal mucosa (nasolacrimal drainage)
Conjunctiva
This deposits more in the lungs than in patients
What is spacer?
What is negatively charged?
When diameter d decreases 2 times, the surface area of each particle decreases ___ times. The combined surface area for the same weight of powder increases ___ times.
What is 4 times and 2 times?
Properties of bacteria that allow them to cross barriers and infect remote parts of the body.
What are endotoxins and amplification through replication
Effect of tear protein binding.
What is decreasing of bioavailability?
The tendency of a substance to absorb water from surrounding leading to a reduction of total dose
Entrapment of large amounts of water
Development of elastic force acting to break the tablet
Formation of 3D network
Multiple water bonding
are mechanisms of
What is swelling of disintegrants?
Surface tension and contact angle of low wettability
What is high surface tension and large contact angle?
Name benefits of Abraxane in Taxol. At least 2
What is:
No solvent toxicity
30 Minute infusion
Higher dosing tolerated
Better response rate
Properties of an ophthalmic drug that allows it to penetrate the cornea
What is hydrophobic and hydrophilic properties
An ideal DPI
What is a DPI that has a consistent dosage of powder within range of inhalation energy levels produced at a comfortable level and to de-aggregate the powder to the smallest possible particle size?
First-line option for manufacturing an API that is unstable in water but has good adhesive properties.
What is direct compression?
This considers interparticle and intraparticle volumes that add to the volume
What is bulk density?