Normal vs. Diseased Anatomy
What changes occur in the lung interstitium due to asbestos exposure?
What is fibrosis?
What common PFT pattern is seen in restrictive lung disease?
What is decreased FVC and TLC with a normal or increased FEV1/FVC ratio?
According to Ohm’s law, what happens to pressure when resistance increases and flow remains constant?
What is pressure increases?
What occupational history clue would raise concern for pneumoconiosis?
What is long-term work in environments with asbestos, silica, coal dust, etc?
How does fibrosis affect alveolar function in gas exchange?
What is that it thickens the alveolar-capillary membrane, impairing oxygen and carbon dioxide diffusion?
What echocardiographic finding suggests cor pulmonale?
What is right ventricular dilation and elevated pulmonary artery pressure?
What component of Poiseuille’s Law has the greatest effect on resistance?
What is radius (to the fourth power)?
How does pleural thickening contribute to restrictive physiology?
What is it limits lung expansion and reduces total lung capacity?
What heart chamber is affected by restrictive lung disease, and why?
What is the right ventricle, due to increased pulmonary vascular resistance from fibrosis?
What symptom and physical exam finding together point to right heart failure in restrictive lung disease?
What are lower extremity edema and jugular venous distension?
In fibrotic lung disease, which factor contributes to increased pulmonary resistance?
What is narrowed capillaries due to fibrotic tissue and vessel remodeling?
What happens to DLCO in restrictive lung disease and why?
What is impaired diffusion capacity due to alveolar-capillary membrane damage?
Why did tricuspid regurgitation develop in Mr. Pachoute's case?
What is that chronic pulmonary hypertension from restrictive lung disease caused right ventricular dilation, which stretched the tricuspid valve annulus and led to regurgitation?
What ABG abnormality is typically seen in restrictive lung disease?
Daily Double!
What is hypoxemia, sometimes with respiratory alkalosis?
Why?
How do Ohm’s and Poiseuille’s laws together explain the development of pulmonary hypertension?
Daily Double!
What is that increased resistance (via vessel narrowing and fibrosis) raises pressure in pulmonary arteries, straining the right heart?
Why does pulmonary hypertension develop in pneumoconiosis patients?
What is chronic hypoxic vasoconstriction and vascular remodeling due to interstitial fibrosis?