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100
This diagnostic test, commonly thought of as part of MS diagnostic workup, is no longer a part of 2010 McDonald criteria for RRMS.
CSF (oligoclonal bands, IgG index)
100
The allele most strongly associated with MS
What is HLA-DRB1*15:01?
100
Neuropsychological cognitive testing is the gold standard for detecting and monitoring cognitive impairment in MS. Because of its length and complexity, however, it is not adequate as a screening tool. BICAMS (Brief International Cognitive Assessment in MS) is one such screening tool, that takes 10-15 min to administer. What are the tests that comprise BICAMS battery?
What is SDMT (proc speed), BMVT-R (visual memory); CVLT-II (verbal memory)?
100
Answer to one of which 2 questions detects depression among MS patients with 98.5% sensitivity?
What is "During the last two weeks, have you often been bothered by feeling down, depressed, or hopeless? —2. During the past two weeks, have you often been bothered by little interest or pleasure in doing things? "
100
A patient has been receiving natalizumab (Tysabri) for 56 months, has a history of immunosuppression, and is JCV antibody negative. What is her risk of developing PML?
What is <1/1000?
200
Annual rate of brain volume loss among normal individuals is about 0.2%. What is this rate for people with MS?
What is 0.7-1.2%
200
Monthly lab monitoring is required for how long after the use of alemtuzumab (Lemtrada)?
What is 48 months (4 years)?
200
Oligoclonal bands are found in 70-90% of MS patients. For Asian MS patients specifically, what is this percentage?
What is 33%
200
Following a MS relapse, what is the likelihood of incomplete recovery?
40-44% have 0.5 point increase in EDSS at 30-90 days after relapse?
200
According to the last (2013) consensus statement on defining the clinical course of MS, the course can be characterized as CIS, relapsing or progressive; active or non-active; and worsening or non-worsening. What frequency of brain MRI scans is recommended to assess activity in the relapsing MS?
What is annually?
300
Which modifiable environmental risk factor correlates with the progression of MS?
What is smoking? REF:Arch Neurol. 2009;66(7):858-864
300
What are the criteria for dissemination in space for PPMS, according to 2010 McDonald criteria?
What is 2 of 3: 1. DIS in the brain based on 1+ T2H in a typical area 2. DIS in the spine based on 2+ T2H in the cord 3. Positive CSF (OCB or IgG index
300
The first trimester postpartum is recognized as the time of increased risk of relapse, according to PRIMS study. What percentage of women in this study did not have a postpartum relapse?
What is 72%?
300
Autologous hematopoietic stem cell transplantation has been explored in MS as a treatment option. What percentage of patients had return of MS disease activity within 3 years after AHSCT?
What is 21.4%?
300
Uveitis in which location is most commonly associated with MS?
What is intermediate?
400
Among various measures of brain atrophy, this measure shows the best correlation with disability and prognostic value.
What is Whole brain atrophy?
400
A patient with transverse myelitis with corresponding lesion at T4 and 1 supratentorial juxtacortical lesion needs to have how many infratentorial lesions to meet 2010 dissemination in space criteria?
What is 2?
400
What fraction of US Caucasian population has the allele most strongly associated with MS?
What is 20-25%
400
GLATiramer is composed of Glutamate, Lysine, Alanine and Tyrosine joined by peptide bonds. Which of these amino acids is present in the highest molar ratio?
What is alanine?
400
The use of this class of medications in assisted reproduction technique, unlike others, is not associated with the increase in MS relapse risk.
What is GnRH antagonists?
500
Fingolimod sequesters a subset of T cells, including naïve T(n) and central memory T(cm) cells, by depleting S1PR on cell surface. Effector T cells, however, are not sequestered because they lack this surface molecule that anchors T(n) and T(cm) cells.
What is CCR7?
500
This biological assay was used by the FDA to establish sameness of generic and brand glatiramer
What is EAE?
500
Risk of fingolimod-associated macular edema in general population is 0.6%. What is the risk of macular edema in patients with prior history of uveitis?
What is 20%?
500
Some SSRIs are associated with increased risk of torsades des points, owing to their effect on prolonging the QT interval. Which SSRI shortens that QT interval?
What is fluvoaxamine? sertraline (3 msec) citalopram (6 msec) escitalopram (7 msec); fluvoxamine (shortens QT interval)
500
This rare complication of interferon-beta treatment presents with hypertension, thrombocytopenia, seizures, and acute renal failure
What is thrombotic microangiopathy (TMA)?