Call me on my T-cell
Don't shoot the messenger.... RNA
Hot Science Club (HSC)
Gents & Ladies, Meet Mercedes
About Somebirdy
100

This is the starting cell population for bb2121.

What are PBMCs?

100

This is the type of nuclease the mRNA codes for.

What is MegaTAL?

100

This severe genetic disease is targeted by Lenti-D drug product.

What is cerebral ALD?

100

Mercedes leads with this Insights color.

What is Red?

100

This is Pinky's real name.

What is Pinky?

200

This is a surface marker expressed on all T-cell subsets.

What is CD3?

200

This 3' structure is important in protecting mRNA from degradation.

What is a 3' poly-A tail?

200

This marker is used to isolate a patient's hematopoietic stem cells.

What is CD34+?

200

She has citizenship in these following 2 countries.

What are Argentina and Spain?

200

These two birds flew all the way from their nest in Texas.

Who are Ashley and Fritz?

300

This occurs on D1 of the DP process.

What is transduction?

300
This is the enzyme used for adding a 5' Cap to the mRNA.

What is Vaccinia?

300

This instrument is used to wash and label an apheresis product.

What is the Sepax?

300

This is Mercedes' favorite genre of music as a teenager.

What is hard rock?!

300

This little birdie is Mark O's first born.

Who is James?

400

This is the reagent used to separate blood in order to generate the starting material for bb2121.

What is Ficoll?

400

mRNA is purified by this type of affinity capture chromatography.

What is Oligo-dT purification?

400

In this year the ALD program was announced.

When is 2009?

400

Mercedes joined bluebird bio due to her work and research in this following area.

What is vector/ virology?

400

Two of our birds completed their pHD at this institution. In fact, they had the same PI.

What is University of Illinois Urbana-Champaign?

500

This is the cytokine added to T-cell growth media.

What is IL-2?

500

This is the type of DNAzyme used by mRNA AD to release 5' Cap and 3' Tail.

What is 10-23 DNAzyme?

500

This is the transduction volume for the small-scale process.

What is 100 microliters?

500

Mercedes lived in the following five countries.

(Hint: On 3 different continents)

What are US, Canada, Spain, Brazil and Argentina?

500

This bird has nested here at bluebird the longest.

Who is Alden Ladd?