SIRS
The definition of SIRS
What is Systemic Inflammatory Response?
One infection criteria
How many Infection Criteria are needed for a positive infection screening?
1 criteria
What is the amount of organ dysfunction criteria needed for a positive sepsis screen?
Extra blood flow to the site of infection which causes redness and heat
What is vasodilation?
The time the patient meets all 3 Sepsis screening criteria within 6 hours of each other
What is time zero?
Two SIRS criteria
What is the minimum amount of SIRS criteria needed to screen positive?
Positive culture results from blood, urine, sputum
WBC's in normally sterile fluid (urine, CSF)
What are labs monitored for infection criteria?
Lactate > than 2
What is the Lactate level for positive organ dysfunction?
Increased permeability allows plasma and proteins to leak out of the vascular space and into the tissue.
What is 3rd spacing or edema?
Initial lactate measurement, blood cultures prior to anitbiotics, antibiotics administered, and 30ml/kg of crystalloid fluids (NS or LR) if SBP<90, MAP<65, decrease in SBP by >40 mmhg or lactate > or = 4 mmol/L
What is the 3-hour bundle?
Labs WBC, blood glucose level (non-diabetic patient)
What labs are screened for SIRS criteria?
Antibiotic therapy (Not prophylaxis)
What is the type of antibiotic therapy which qualifies for infection criteria?
SBP and MAP
What are the vital signs measured for organ dysfunction?
Hypoxia, decreased clearance by the liver, and Respiratory alkalosis
What causes increased blood lactate?
Two consecutive BP readings: SBP<90, MAP>65 or decrease in SBP by >40 within the 1st hour following fluid administration
(check BP every 15 min after fluid bolus)
What is persistent hypotension?