Enter Title

Drug Target

100

A protein that speeds up the rate of a chemical reaction (catalyst)

Enzyme

200

A protein the helps move molecules through cell membranes, sometimes requiring ATP

Transporter

300

A protein on the cell surface that transduces a signal from outside the cell to the inside of the cell

Membrane receptor

400

A protein that permits charged molecules to move through a cell membrane

Ion channel

500

A protein inside a cell that transduces a signal to cause changes in gene expression

Nuclear receptor

Dose-Response

100

The term describing the drug concentration associated with a specific response

Potency

200

The term referring to the level of response of a drug

Efficacy

300

A drug that produces <100% response

Partial agonist

400

A drug that produces maximal response (100%)

Full agonist

500

A drug that binds a receptor but fails to stimulate a second messenger

Antagonist

Drug Therapy

100

The range of drug doses causing safe, effective therapy

Therapeutic window

200

Comparing drug concentration-receptor binding curves for a single drug and different receptors can tell this

Drug selectivity for receptor binding

300

The effective dose of a drug that produces a 50% response is called this

ED50

400

This type of drug will shift the dose-response curve of an endogenous agonist to the right

Competitive antagonist

500

Comparison of the drug dose causing a therapeutic benefit to that dose causing a toxic effect is often called this

Therapeutic index