Guess that drug class!
Mechlorethamine
Melphalan
Ifosfamide
Cyclophoshamide
chlorambucil
what are nitrogen mustards?
Imatinib
Erlotinib
Geftinib
Inability of cell to separate double helical DNA; initation of DNA repair mechanism
What are alkylating agents/anthracycline antibiotics/ anthracenedione antibiotics?
causes intra- and inter-strand cross links (Cross-bridges)
loss of DNA fidelity (or exact replication- leads to mutation and loss of protein function)
what are triazenes?
Temozolomide
Decarbamine
what are triazenes?
Tamoxifen
Toremifene
what are anti-estrogens? (Hormone receptor antagonist)
Inability of cells to unwind DNA
what are topoisomerase I/II inhibitors?
Hydroxyurea
what is inhibition of ribonucleotide reductase
Immune system directed cell lysis or apoptosis of the neoplastic cells
what are immune stimulants?
Etoposide
Teniposide
what are podophyllotoxins ? (topoisomerase II inhibitors)
Vinblastine
Vincristine
what are mitotic inhibitors? (vinca alkaloids)
Inabilitity of cells to synthesize deoxyribonucleosides and synthesize new strands of DNA
what is Gemcitabine/fludarabine?
cytarabine
prodrug (converted into a triphosphate)- incorporated into replicating DNA causing inhibition of DNA polymerase
Inability of cells to synthesize new strands of DNA (loss of cellular proliferation
what are any of the anti-metabolites BUT bortezmomib?
capecitabine, floxuridine
what are anti-metabolites?
Ibritumomab
Brentuximab
what are conjugated antibiotics?
what are anti-androgens?
Paclitaxel
Docetaxel
what is inhibition of de-polymerization of microtubulins into tubulin ?
Inability of cells to proliferate and metastasize; increase in cellular apoptosis
what are protein kinase inhibitors?
Cladribine
what are anti-metabolites?
Trastuzumab
Bevacizumab
Ceftuximab
Inability of cells to produce estrogen from precursors
what are aromatase inhibitors? (Anastrozole, Exemestane, letrozole)
pentostatin
what is inhibition of adenosine deaminase-disruption of nucleic acid metabolism resulting in inhibition of ribonucleotide reductase?
Induction of apoptosis due to presence of pro-apototic proteins
what is Bortezomib?