Trokendi XR
Preventive migraine medications can reduce the likelihood of migraine occurrence by ______ or more.
50%
Which of the following are considered to be the two major subtypes of migraine, as defined by the ICHD-III guidelines?
A) Migraine with aura; chronic migraine
B) Migraine without aura; episodic migraine
C) Migraine with aura; migraine without aura
D) Migraine without aura; complications with migraine
C) Migraine with aura; migraine without aura
What is the half-life of the chemical oxcarbazepine and the active metabolite MHD, respectively?
About 2 hours and 9 hours
The most common comorbid condition associated with people with epilepsy is:
Depression
Which one of these government plans is a federally funded plan for elderly individuals and those on social security disability?
The acronym NSAID stands for:
Nonsteroidal Anti-Inflammatory Drug
The ______ pathway conveys pain information from the meninges to the brain.
Trigeminovascular
Compared to Trileptal, Oxtellar XR takes ________ to reach peak plasma concentrations in the bloodstream.
A longer time
_____ % of patients are estimated to not take their AEDs as directed.
50%
True or False. A sales representative may assist a physician in filling out a prior authorization as long as that representative is not exposed to any of the patient’s personal information.
False
Which of the following statements are true about Trokendi XR and the use of oral contraceptives? Select all that apply.
A) The efficacy of Trokendi XR is lessened when oral contraceptives are taken.
B) The efficacy of the contraceptive is lessened with taken with Trokendi XR.
C) Interactions with oral contraceptives are much greater at doses of 200mg or higher of Trokendi XR.
D) Topamax does not have a drug-to-drug interaction with oral contraceptives because it does not utilize the Microtrol delivery system
B) The efficacy of the contraceptive is lessened with taken with Trokendi XR.
C) Interactions with oral contraceptives are much greater at doses of 200mg or higher of Trokendi XR.
Which of the following were the treatment arms in Topamax's 2 adult Phase 3 studies?
A) Placebo, 50 mg, 100, mg and 200 mg
B) Placebo, 50 mg, and 100 mg
C) 50 mg, 100 mg, and 200 mg
D) Placebo, 100 mg, and 200 mg
A) Placebo, 50 mg, 100, mg and 200 mg
What makes up the treatment phase for a clinical trial? Select all that apply.
A) Maintenance
B) Titration
C) Washout period
D) All of the above
A) Maintenance
B) Titration
Which of the following tests are used to plan for a patient’s surgery? Select all that apply.
A) MRI
B) PET
C) SPECT
D) EEG
B) PET
C) SPECT
The purpose of managed care is to ________.
Provide quality healthcare
Trokendi XR was approved under a regulatory pathway referred to as _____________.
505 (b)(2)
According to Topamax's Phase 3 trials, what is the challenge of getting a patient to the 100mg suggested maintenance dose?
Titrating a patient to 100mg may come with significant tolerability concerns.
What was the discontinuation rate for the Oxtellar XR 2400 mg/day group in the Prosper trial?
30%
It is not fully understood how AEDs work, but core mechanisms of action are postulated to work on:
Sodium ion channels
Which government plan is jointly funded at the federal & state levels for low-income individuals and families?
Medicaid
Which of the following statements is true about the “Partial AUC” for Trokendi XR?
A) Partial AUC was one of the three parameters used to assess the results.
B) The partial AUC data was a key factor in Trokendi XR’s approval.
C) The FDA found Trokendi XR’s partial AUC to be invalid.
D) Partial AUC has little significance for Trokendi XR.
B) The partial AUC data was a key factor in Trokendi XR’s approval.
What is the phenomenon of the wave of electrical hyperactivity followed by a wave of inhibition?
Cortical Spreading Depression
Which of the following warnings and precautions is listed in Trileptal’s PI, but NOT in Oxtellar XRs? Select all that apply.
A) Hyponatremia
B) Hematologic events
C) Cognitive/neuropsychiatric adverse events
D) Anaphylactic reactions & angioedema
C) Cognitive/neuropsychiatric adverse events
What percentage of patients have refractory epilepsy?
33%
Which of the following are true about Commercial Healthcare Plans? Select all that apply.
A) Medical coverage that is provided by an employer or purchased by an individual
B) Premiums are paid in exchange for insurance
C) Employers often assist in paying for health benefits
D) Medical coverage that is funded by BOTH the state and federal government.
A) Medical coverage that is provided by an employer or purchased by an individual
B) Premiums are paid in exchange for insurance
C) Employers often assist in paying for health benefits