DEPRESSION
Which antidepressants are strong 2D6 inhibitors? 1A2 inhibitors? (3) Brand names
Wellbutrin, Paxil, Prozac- 2D6
Luvox - 1A2
Which benzos undergo phase II metabolism?
LOT drugs
Lorazepam, oxazepam, temazepam
Which drug is FDA-approved for schizoaffective disorder? AND maximum dose...
Paliperidone, 12 mg
Clozapine and lithium
Which drug works as a 5HT2a inverse agonist? Brand and generic name
Pimavanserin (Nuplazid)
Which disorder presents as hyper-reflexia, nausea, vomiting, tremors, AMS, and sweating?
Serotonin syndrome
Which drugs are FDA-approved for social anxiety disorder?
Paroxetine, sertraline, venlafaxine
What class of medication treats neuroleptic malignant syndrome? Give an example.
Dantrolene, bromocriptine. Dopamine agonists
Which mood stabilizers cause blood dysgrasias?
Carb- aplastic anemia and agranulocytosis
Dep- thrombocytopenia
Lithium- leukocytosis
What are the rating scales that look at depression, mania, and schizophrenia in clinical trials?
HAMD/MADRS, YMRS, PANSS
Which SSRI is the most anticholinergic? (Brand name)
Paxil
Which antidepressant was previously taken off the market because of hepatotoxicity? It is currently back on the market... Brand name
Serzone
100 mg of chlorpromazine is equivalent to ___ mg of fluphenazine and ___ mg of perphenazine.
2 mg- flu
8 mg- per
What is the mechanism of gabapentin, the max dose, and how is it cleared?
Inhibits voltage gated calcium channels, 3600 mg, and it is cleared renally!
For an extra 200 points, give me two off-label uses of gabapentin.
Recall the drug levels (with units) for lithium, carbamazepine, divalproex, and nortriptyline
lithium 0.4-1.2 mEq/L
carb 4-12 mcg/mL
dival 50-100 (120) mcg/mL
nortrip 50-150 mcg/mL
What is considered response and remission in depression?
HAMD< 8 remission; 50% response, 70% remission
At what doses of mirtazapine and trazodone do we target for sleep?
mirtazapine- 7.5-15 mg
trazodone < 200 mg
Of the following, which is first and last to response to antipsychotic therapy (and the time frame):
- delusions
- agitation/hostility
- hallucinations
1. agitation/hostility --> hours to days
2. hallucinations --> 1-2 weeks
3. delusions --> 2 weeks to months
List 6 monitoring parameters of Depakote.
Weight, VPA level, CBC, LFTs, pregnancy, Lipids, Ammonia
Which three 2nd gen AP are metabolized by 1A2? And what are the max doses?
Asenapine (20), Olanzapine (20), Clozapine (900)
Which antidepressants have active metabolites where both are currently on the market? Give at least 2 pairs
Amitriptyline- Nortriptyline
Venlafaxine - Desvenlafaxine
Imipramine - Desipramine
Amenorrhea is a symptom of what hypnotic medication? What schedule is this medication?
Ramelteon, not controlled
Drug manufacturer of:
1. Invega Sustenna
2. Abilify Maintena
3. Zyprexa Relprevv
1. Janssen
2. Otsuka
3. Eli Lilly
What is the brand name for carbamazepine for bipolar disorder, what is the maximum dose, and what is the timeline for autoinduction?
Equetro, 1600 mg, autoinduction is the greatest after starting the medication (1-4 weeks) and then usually will be constant after that.
What allele are we worried about with for carbamazepine and SJS?
The HLA-B*1502 allele is highly associated with the outcome of carbamazepine-induced Stevens–Johnson syndrome and toxic epidermal necrolysis