Cancer Biology/ Immunology
Most common HLA-I allele
HLA-A02
This domain of the CAR binds to the antigen target
Single-chain variable fragment (scFV)
The year the first CAR-T therapy was FDA approved
2017
CEO of Allogene Therapeutics
David Chang
This fruit has the highest calories of any fruit.
What is an avocado?
This class of therapy prevents the "off" signal from being sent to T cells
Most common side-effect of CAR-T therapy
This company had the first CAR-T FDA approval
Novartis
Date Allogene Therapeutics was founded
May 1, 2018
This large country is the world's leading producer of bananas
What is India?
Class of proteins that are normally only expressed during fetal development but are expressed in adult cancerous cells
Oncofetal antigen
2nd-generation CARs has this domain that 1st-generation CARs does not have
Costimulatory signaling domain (CD28 or 4-1BB)
Current number of FDA-approved CAR-T therapies
Six
Name of our in-house manufacturing site for AlloCAR-T
Cell Forge 1
It is illegal for a plane to fly over this Indian marvel.
What is the Taj Mahal?
Cancer cells express this protein to stimulate the formation of blood vessels
Vascular endothelial growth factor (VEGF)
This CAR domain precedes (upstream of) the antigen-recognition domain
Signal peptide
First BCMA CAR approved by FDA
Abecma (idecabtagene vicleucel)
Program name for our BMCA TurboCAR
ALLO-605
Butterflies use this body part to taste
What is their feet?
This immunosuppresive cytokine can be found in the tumor microenvironment
Transforming growth factor beta (TGF-b)
This commonly used CAR hinge can be bound by natural killer cells, neutrophils and macrophages
IgG1 or IgG4-based hinge
This company knocks out PD-1 in their allogeneic CD19 CAR-T
Caribou Biosciences
Month/Year when FDA cleared investigation new drug (IND) application for ALLO-501
January 2019
What does Wi-Fi stand for?
What is wireless fidelity