Neurotransmitters
Decreased level of what NT is most associated with Depressed mood, poor sleep, and poor impulse Control, and affective aggression?
Serotonin
Most appropriate brief screening instrument that a pt can fill by him/herself at physician’s office to screen for depression is (3x)
BECK DEPRESSION INVENTORY
Which SSRI can increase the serum concentration of Alprazolam? (Xanax)
Fluvoxamine (via CYP3A4 inhibition)
Most common inherited mental retardation: (2x)
Fragile X
The new onset of pathological gambling, increased libido, and hypersexuality in a patient with Parkinson disease is likely to be secondary to: (3x)
PRAMIPEXOLE
Which neurotransmitter is predominantly inhibitory?
Glycine
What test would be considered most useful to specifically evaluate concept formation, reasoning, and executive functioning? (5x)
WISCONSIN CARD SORTING TEST (WCST)
What drug has a curvilinear therapeutic window? (6x)
NORTRIPTYLINE
4 y/o child that was hypotonic as an infant is now demonstrating developmental delays, foraging for food and having many temper tantrums. Dx? (4x)
PRADER-WILLI SYNDROME
19 y/o pt reported hearing a voice that talked about what pt was thinking. The pt’s speech has a normal rate and rhythm, but says things such as, “It is white, very white. I know. Things are that way. They are. I am.” (Poverty of speech and content) This speech is an example of: (3x)
ALOGIA
Where are the major clusters of cell bodies containing serotonin in the brain?
RAPHE NUCLEUS IN THE BRAIN STEM
Which test is an objective measure of personality in adults and is helpful in confirming diagnosis of personality disorder? (3x)
MILLON CLINICAL MULTIAXIAL INVENTORY (MCMI)
Psychiatrist is called to eval a pt on a medical floor who has developed acute dysarthria w/ protruding tongue and torticollis. Which med is suspect? (2x)
METOCLOPRAMIDE
Adult pts with velocardiofacial syndrome (chromosome 22q11 deletion syndrome) are at substantially increased risk for developing which psychotic d/o? (3x)
Schizophrenia
A 35 yo F patient has discoid lupus which has long been controlled with a stable dose of oral prednisone. She abruptly develops increased fatigue, inflamed joints, and diffuse myalgias. Pt also exhibits depressed mood and cognitive impairment. She has no prior psychiatric history and no focal neurological signs. Which of the following is the most likely etiology? (2x)
DISEASE INDUCED CEREBRITIS
Which neurotransmitter, IF dysfunctional, most replicates core symptoms of schizophrenia?
Glutamate
An appropriate purpose for projective testing is: (3x)
DETECTING THE PRESENCE OF SUBTLE PSYCHOTIC THOUGHT PROCESSES
Which opioid has a potentially lethal interaction with monoamine oxidase inhibitors (MAOIs)? (
MEPERIDINE
Apoptosis of cortical neurons differs from necrosis in that it: (2x)
INVOLVES EXPRESSION OF SPECIFIC GENES
A 20 year old male pt presents to his physician for a physical examination because he is worried that he may have contracted an infectious disease. He states that his worry is interfering with his ability to complete work assignments. He states that he counts to 100 repetitively in order to distract himself from this worry. He has no prior medical or psychiatric history. He does not abuse substances and is not involved in any relationships. Which of the following regions of the pt’s brain is most likely to show increased activity on PET scan? (2x)
CAUDATE
A compound that increases muscle mass by increasing episodic secretion of GH (2
GAMMA HYDROXYBUTYRATE
What psychological tests measure test-taking attitudes at time of exam (4x)
MMPI (MINNESOTA MULTIPHASIC PERSONALITY INVENTORY) VALIDITY SCALE
Antidepressant preferred for >65 y/o for which blood levels are clinically useful (3x)
DESIPRAMINE
Metachromatic leukodystrophy associated w/ mutation in a gene for which enzyme? (2x)
Aryl Sulfatase
What is associated with a markedly increased risk of complications from ECT? (2x)
COPD