Platelet
Disorders
Disorders
What is the precursor to platelets?
Megakaryocytes
What medication can be used for minor bleeding and prophylactic for surgery/procedures in von Willebrand disease?
Desmopressin
How must PRBC and platelets be modified to decreased the transmission of CMV?
Leukoreduction: decreases number of leukocytes present in transfused erythrocytes or platelets
Which gene mutation is associated with an elevated homocysteine level and a modest increased risk of venous thrombosis?
Methylene tetrahydrofolate reductase (MTHFR)
What is the management of acute fatty liver of pregnancy?
Supportive and early delivery of baby
Which resident as been to 6 out of the 7 wonders of the world?
Sydney
What are the 4 T's in the 4T scoring system for HIT?
Thrombocytopenia
Timing of platelet count decrease
Thrombosis or other sequelae
Other causes for thrombocytopenia
CBC, PT, and aPTT seen with Hemophilia A and B?
Normal CBC
Normal PT
Prolonged aPTT
How much does one unit of PRBC raise the hematocrit (%) AND the hemoglobin (g/dl) of an averaged sized non-bleeding adult?
Hematocrit - 3%
Hemoglobin - 1 g/dl
At what creatinine clearance should fondaparinux be avoided?
less than 30 mL/min
What does the T in TNM cancer staging system represent?
Which resident went to boarding school?
What are the typical characteristics of hemolytic uremic syndrome?
What are the classic laboratory findings for DIC (6 labs)
thrombocytopenia, prolonged aPTT, prolonged PT, elevated INR, hypofibrinogenemia, elevated D-dimer
What is the most important step in treatment for acute hemolytic transfusion reactions?
Discontinuing the transfusion
How many month of anticoagulation should a provoked upper extremity DVT be managed with?
3 months
What is the treatment of choice for pregnant women with VTE?
LMWH
Which resident caught a bat in a hospital?
Arjun
Which TWO diagnosis should you consider for a patient who presents with mucocutaneous bleeding, normal CBC, normal PT, and normal aPTT?
von Willebrand disease or acquired platelet disorder
What is the mechanism of action for Vitamin K?
It acts as a cofactor for carboxylation and activation of coagulation factors II, VII, and X.
If a patient has an anaphylactic reaction to a blood transfusion, what two underlying protein deficiencies should be investigated?
IgA and haptoglobin
Name two situations when non-vitamin K antagonist oral anticoagulants should not be used in patients.
Pregnant women should receive IVIG or glucocorticoids to treat ITP at what platelet count?
<30,000
Which resident played on the basketball team in high school?
Nathalia
What are the two ways to treat immune thrombocytopenia purpura if the patient is symptomatic (or when platelets are <30,000)? How do you treat it if they are asymptomatic?
Symptomatic: glucocorticoids or intravenous immune globulin
Asymptomatic: careful observation
What happens when you give patient's with Acquired Hemophilia Factor VIII concentrates, and why?
It does not correct the problem because of the presence of an inhibitor.
They should receive activated prothrombin complex concentrates or activated factor VII for management of acute bleeding.
What modifications should be made to blood products for patients that have undergone stem cell transplant?
As long as the catheter remains in place.
NSAIDS should be avoided in pregnant women with SCD until after what week of gestation?
30th week of gestation
Which resident was bit by a TRAUMATIZING brown recluse spider?
Sowmya