Pharm Neuro/GU Jeopardy

Neuro 1

100

Used for migraines. Can cause heaviness in chest due to vasoconstriction. Should be avoided by people with coronary artery disease, angina, or have had an MI. 

sumatriptan

200

Can lead to gingival hyperplasia, skin rash, or CNS depression

phenytoin

300

Abrupt discontinuation leads to rebound spasticity, fever, muscle damage

baclofen

400

Can cause flu-like symptoms and myelosuppression, leading to decreased cell counts. Used to treat multiple sclerosis.

Interferon beta-1a

500

May cause bradycardia, nausea, dizziness, and GI symptoms. Treats Alzheimer's.

donepezil

Neuro 1

100

May cause life threatening cardiac arrhythmias. Must monitor distal sites if epinephrine is added to prolong effect. Used as local anesthetic.

lidocaine

200

Used in ICU or surgery setting only. Killed MJ.

propofol/methohexital sodium

300

May cause insomnia, hypertension, tachycardia, and palpitations. Weight loss should be monitored. Toxicity can cause psychosis, dysrhythmias, or seizures.

amphetamine

400

Used in conjunction with to assist with anesthesia. Induces state of amnesia. Potential for respiratory and cardiac arrest. Benzodiazepine.

midazolam

500

CNS effects - dizziness, headache, increased confusion. Better tolerated than cholinesterase inhibitors. Used to treat Alzheimer's.

memantine

Neuro 2

100

May cause paradoxical anxiety and mild CNS effects. Grapefruit juice may cause drug toxicity. 

buspirone

200

Causes miosis. Encourage adequate lighting in home. May cause retinal detachment.

pilocarpine

300

Increased risk of suicide with initiation. GI symptoms common. May cause hyponatremia, especially with diuretics.

venlafaxine

400

Very narrow therapeutic index. Hyponatremia can cause drug toxicity. Needs very close monitoring.

lithium

500

Tyramine foods like aged cheese can cause hypertensive crisis with this.

phenelzine

Neuro 2

100

If systemically absorbed may cause bradycardia, hypotension, bronchospasm. Apply pressure to puncta and nasolacrimal sac with administration.

betaxolol

200

Drowsiness, sedation, orthostatic hypotension, and tachycardia. Overdose causes cardiotoxicity. May increase risk of suicide. 

amitriptyline

300

Abruptly stopping can cause seizures and other withdrawal symptoms. If giving IV, can cause phlebitis. Antidote is flumazenil. 

diazepam

400

Associated with tardive dyskinesia and extrapyramidal side-effects. Can cause neuroleptic syndrome.

chlorpromazine

500

Can cause CNS effects. Extrapyramidal side-effects can occur but not as often as with conventional classes. Helps with treatment of schizophrenia.

risperidone

GU/Repro

100

Increased risk for thromboembolism and hypertension. Patients should not smoke while taking this. Many other drugs decreased its efficacy.

conjugated equine estrogen

200

May cause osteoporosis. Induces menopausal symptoms. Used to treat endometriosis. 

leuprolide 

300

Might cause priaprism. Should not be taken with nitrates. 

sildenafil

400

Anticholinergic. Causes urinary retention. 

oxybutynin

500

May cause ovarian hyperstimulation syndrome. Increases risk for multiple gestation pregnancy. Helps to treat infertility.

clomiphene