Pregnancy or not
Which SSRI to avoid in pregnancy?
Paroxetine
Which dopamine pathway controls the development of EPS?
Nigrostriatal pathway
CNS diseases such as TBI or seizures INCREASE or DECREASE threshold for CNS side effects
Decrease
What 3 benzodiazepines are not metabolized by CYP3A4?
LOT (lorazepam, oxazepam, tamazepam)
What two meds have Stevens-Johnson syndrome as a warning
Carbamazepine
Lamotrigine
Lithium exposure in the 1st trimester increases the risk of:
Ebstein's anomaly/cardiac malformations
What two EPS syndromes are more likely to occur in elderly females?
Drug-induced parkinsonism and tardive dyskinesia
Antidepressants that are the lowest risk for GI bleeding (hint: 2 of them)
Mirtazapine and Bupropion
Name 2 antidepressants that inhibit CYP2D6?
Paroextine, fluoxetine, bupropion, duloxetine
Elderly patients with dementia have increased risk of death with which class of meds?
Antipsychotics
SSRI use in pregnancy increase the risk of what in the newborn?
Persistent Pulmonary Hypertension (from 2 in 1000 to 3 in 1000)
What two neurotransmitters are responsible for EPS?
DA and Ach
What antidepressant is preferred in short-gut syndrome?
escitalopram
What two antipsychotics are primarily metabolized by CYP 1A2?
Clozapine and Olanzapine
Name 3 warnings with clozapine
Severe neutropenia, myocarditis, orthostatic hypotension, seizures
Which mood stabilizer decreases contraceptive efficacy?
Lamotrigine
Which EPS is the most deadly? and why?
Acute dystonia leading to laryngospasm
Name 2 drugs that can be removed by dialysis?
Lithium, Gabapentin, Pregabalin, Valproate, topiramate, levetiracetam
Fluvoxamine is a potent inhibitor of: (name 1)
1A2 and 2C19
Name one drug with black box warning for hepatotoxicity?
Valproate and Naltrexone
What mood stabilizer/antipsychotic is the safest in breast feeding?
Quetiapine or Olanzapine
Which rating scale assesses for all EPS
Extrapyramidal Rating Scale (ESRS)
What antidepressant can you not give in liver disease?
Duloxetine
Patient is on tamoxifen and codeine, what enzyme metabolizes these drugs?
CYP2D6
Suicidality in adolescents and young adults, of the 3 antipsychotics that are listed, name 2:
Abilify, Brexipiprazole, quetiapine