Lynch
What are the endometrial cancer screening recommendations for women with Lynch syndrome?
EMB Q1-2 years starting at age 30-35 in women with lynch
Name a type of iatrogenic acquired amenorrhea
Asherman Syndrome
What vulvar dermatosis presents with "cigarette paper" appearance and involvement of the superior vulva and perianal tissue creating a "figure of eight"
Lichen Sclerosis
Who is our "newest" / most recently graduated attending?
Dr. Foucher <3
What are the colon cancer screening recommendations for patient's with Lynch?
Colonoscopy every 1-2 years starting at age 20-25 or 2-5 years before earliest diagnosis
Define primary amenorrhea
Absence of menarche by age 15 years
Absence of breast development by age 13 years
Appears as one or more erythematous, scaling, or lichenified plaques. Various degrees of excoriation are often visible.
How many children does Dr. Witters have?
Two kiddos! Boy and girl
What is the inheritance pattern of Lynch and what is the fundamental etiology of the pathogenesis?
Autosomal dominant pattern causes defects in mismatch repair
Patient presents with developed breasts, absent uterus, no pubic or axillary hair, and serum testosterone levels in the normal male range. What is your suspected diagnosis?
Androgen Insensitivity Syndrome
Describe the clinical presentation of lichen sclerosus
Vulvar pruritis, irritation, burning, dyspareunia, and tearing. Porcelain-white papules and plaques, often with areas of ecchymosis (or purpura)
Where did Dr. Kiley train?
Sparrow (gross)
But we love her, anyways <3
Name 4 common genetic mutations associated with Lynch
MLH1
MSH2
MSH6
PMS2
What is the initial workup for amenorrhea
Beta HCG
FSH
E2
TSH
PRL
+/- serum T if signs of hyperandrogenism
Describe the clinical appearance of classical (papulosquamous) lichen planus
Symptoms of dyspareunia, burning, soreness, itching, and increased vaginal discharge. Appears as white, reticulate, lacy, or fernlike striage (Wickham striae). Dusky pink, poorly demarcated papules may be present.
Where did Dr. Kota train?
Corewell health (Butterworth) Grand Rapids
Which genetic mutation confers the highest risk for developing endometrial cancer?
MLH1
Pt is a G2P2 presenting 9 months postpartum with no resumption of normal menses. History reveals significant postpartum hemorrhage due to retained placenta that was managed with D&C. What is your suspected diagnosis and what is the management of this condition?
Asherman Syndrome (formation of intrauterine adhesions)
Hysteroscopic lysis/resection of adhesions
What vulvar dermatosis can have oral involvement?
Erosive lichen planus
What college football team does Dr. Seiler root for?
Iowa Hawkeyes