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200
What number is the universal gas constant (R)?
8.314 J mol-1 K-1 or 0.08206 L atm mol-1 K-1
200
What is the maximum number of hydrogen bonds that the following molecule can form when solubilized in water?
4
200
For the following diagram, match the letter with the correct corresponding drug types .
Agonist
Partial Agonist
Inverse Agonist
Antagonist
Resting State
A /C = Resting State + Antagonist
B = Agonist
D = Inverse Agonist
E = Partial Agonist
200
Differentiate between Type 1 and Type 2 Diabetes?
Type 1: Immune system mistakenly attacks the beta cells in the pancreas, preventing insulin secretion
Type 2: Body cells and receptors develop resistance to insulin
400
Write out the Henderson-Hasselbalch equation
pH = pKa + log([A-]/[HA])
400
What is the sequence of amino acids in the following polypeptide?
Tyr Gly Gly Phe Leu
400
What is a “spider” scaffold?
a molecule core that allows a variation of functional groups to surround it to find multiple receptor-binding sites
400
Write out the Michaelis-Menten's Equation
600
Consider this equilibrium system:
CO(g) + Fe3O4(s) ⥫⥬ CO2(g) + 3FeO(s)
How does the equilibrium position shift as a result of CO being added?
Equilibrium position shifts toward products
600
How many ATP molecules are formed in anaerobic respiration?
2 ATP molecules (The source of ATP molecules only comes from glycolysis as the electron transport chain and beta oxidation of fat is not active)
600
How does high lipophilicity in a molecule influence its absorption, distribution, and metabolism?
Greater volume of distribution
Higher absorption/permeability through the membrane.
Greater metabolic clearance
600
A neurotransmitter receptor, when activated, coordinates influx of 4 [Cl-] and efflux of 1 [HCO3-]. It is known to be the major source of inhibition in the central nervous system. What is this neurotransmitter?
GABA is the neurotransmitter
800
Under standard conditions, the equilibrium constant is KC = 9.1 x 10-6 for the following reaction:
2Fe3+ (aq) + Hg22+(aq) = 2Fe2+(aq) + 2Hg2+(aq)
Using the information provided, what is delta G°?
28.8kJ/mol
800
In a 0.1M solution of glycine at pH 9.0, what fraction of glycine has its amino group in the -NH3+ from? (pKa of glycine = 9.6)
0.25 or ¼ (for every NH2, there are 4 NH3+)
800
Isoprenaline Undergoes Metabolism to give the inactive metabolite shown. Suggest why this metabolite is inactive
One of the hydroxyl groups on the benzene group has been replaced with a methoxy group. This strips the functional group ability to H-bonds to receptors.
800
What is the name of this protein?
Green Fluorescent Protein
800
Complete the following sentence:
"In the clurb, ______"
"We all fam"