What is the universal gas constant (R)?
8.314 J mol-1 K-1 or 0.08206 L atm mol-1 K-1
What is the degree of degeneracy of the ground state particle in a 3D box? (Prof. Wilson, I'm sorry if the answer is wrong.)
1
For the following diagram, match the letter with the correct corresponding drug types .
Agonist
Partial Agonist
Inverse Agonist
Antagonist
Resting State
A /C = Resting State + Antagonist
B = Full Agonist
D = Inverse Agonist
E = Partial Agonist
Differentiate between Type 1 and Type 2 Diabetes?
Type 1: Immune system mistakenly attacks the beta cells in the pancreas, preventing insulin secretion
Type 2: Body cells and receptors develop resistance to insulin
What is the the Henderson-Hasselbalch equation
pH = pKa + log([A-]/[HA])
What is the sequence of amino acids in the following polypeptide?
Tyr Gly Gly Phe Leu
What is a “spider” scaffold?
a molecule core that allows a variation of functional groups to surround it to find multiple receptor-binding sites
Write out the Michaelis-Menten's Equation
Consider this equilibrium system:
CO(g) + Fe3O4(s) ⥫⥬ CO2(g) + 3FeO(s)
How does the equilibrium position shift as a result of CO being added?
Equilibrium position shifts toward products
What is the name of this experiment?
Stern Gerlach Experiment
How does high lipophilicity in a molecule influence its absorption, distribution, and metabolism?
Greater volume of distribution
Higher absorption/permeability through the membrane.
Greater metabolic clearance
A neurotransmitter receptor, when activated, coordinates influx of 4 [Cl-] and efflux of 1 [HCO3-]. It is known to be the major source of inhibition in the central nervous system. What is this neurotransmitter?
GABA is the neurotransmitter
What is the name of this mechanism?
Fischer-Esterification
The statements about adverse drug reactions are correct except:
A. Dose-related ADRs are predictable based on a drug's pharmacology
B. Dose-unrelated ADR's are rare and unpredictable
C. Allergic reactions are an example of ADR's
D. ADR's can be predicted from animal studies
B. Dose-unrelated ADR's are rare and unpredictable
Isoprenaline Undergoes metabolism to give the inactive metabolite shown. Suggest why this metabolite is inactive.
One of the hydroxyl groups on the benzene group has been replaced with a methoxy group. This strips the functional group's ability to form hydrogen bonds to receptors.
What is the name of this protein?
Green Fluorescent Protein
"I might swerve ____"
"bend that corner."