Congenital
Acute Kidney Injury
Nephrotic Syndrome
Nephritic Syndrome
UTI/Nephrolithiasis
100

This congenital defect positions the kidney in the lower abdomen, often causing the kidney to get caught on the inferior mesenteric artery root during its ascent from pelvis to abdomen.

What is horseshoe kidney?

100

This is the term used to describe the accumulation of waste products (BUN, creatinine) in the blood. 

What is azotemia?

100

Patients will present with pitting edema as a result of this lab finding characteristic of nephrotic syndrome. 

What is hypoalbuminemia? 

100

This nephritic syndrome often occurs following mucosal infections.

What is IgA nephropathy?

100

This is the most common etiologic agent for UTI. 

What is E. coli?

200

(Bilateral/unilateral) renal agenesis leads to oligohydramnios with lung hypoplasia, flat face with low set ears, and developmental defects of extremities.

What is bilateral?

200

Prerenal AKI is defined by this value for serum BUN:creatinine ratio.

What is 20:1?

200

This nephrotic syndrome presents with normal glomeruli on H&E stain and negative immunofluorescence.

What is minimal change disease?

200

Treatment for this nephritic syndrome largely consists of supportive care, unless it progresses to a more severe form of injury/failure (which is rare).

What is poststreptococcal glomerulonephritis?

200

This type of UTI usually does not present with systemic symptoms (i.e. fever).

What is cystitis?

300

The autosomal dominant form of this inherited defect presents in young adults as HTN, hematuria, and progressive renal failure and is highly associated with berry aneurysms.

What is polycystic kidney disease?

300

Muddy brown casts are seen in the urine of this type of AKI. 

What is acute tubular necrosis (intrarenal AKI)?

300

This H&E finding is a hallmark of diabetic glomerulonephropathy.

What are Kimmelstiel-Wilson nodules?

300

This autoimmune disorder generates antibodies against collagen in glomerular and alveolar basement membranes and classically presents in young males. 

What is Goodpasture syndrome?

300

Sterile pyuria and primary clinical symptom of dysuria suggest infection with one of these bacterial agents (2). 

What are chlamydia trachomatis or Neisseria gonorrheae?

400

The autosomal _______ form of polycystic kidney disease presents in infants as worsening renal failure and HTN.

What is recessive?

400

This form of AKI will resolve with cessation of the offending agent (usually a drug).

What is acute interstitial nephritis?

400

Type II membranoproliferative glomerulonephropathy is associated with this autoantibody that causes overactivation of complement and subsequent inflammation. 

Extra: what enzyme does the autoantibody stabilize?

What is C3 nephritic factor?

(stabilizes C3 convertase)

400

Diffuse proliferative glomerulonephritis causes immune complex deposition in this location of the glomerular filtration barrier.

What is subendothelial?

400

This type of kidney stone is not visible on x-ray.

What is a uric acid stone?

500

This inherited autosomal dominant defect results in parenchymal fibrosis and shrunken kidneys.

What is medullary cystic kidney disease?

500

This segment of the nephron is particularly susceptible to nephrotoxic acute tubular necrosis. 

What is the proximal tubule? (highest mitochondrial content in the kidney and high metabolic rate so highly dependent on aerobic ATP production)

500

This nephrotic syndrome presents with a characteristic "spike and dome" appearance on electron microscopy.

What is membranous nephropathy?

500

This is how you pronounce "pauci".

What is "possy"?

500

Urease positive organisms (i.e. Proteus, Klebsiella) will commonly cause this kind of kidney stone.

Extra: how do you treat this type of stone?

What is ammonium magnesium phosphate (struvite)? 

Treated with surgical removal (because of size) and eradication of infection (to avoid recurrence)