Symptoms
Mechanism of Action
Side Effects
Levodopa Basics
100

What is the name for slow movement often seen in Parkinson's disease?

What is bradykinesia?

100

Dopamine agonists relieve Parkinson’s symptoms by acting directly on these brain structures.

What are dopamine receptors in the basal ganglia?

100

These digestive issues are common side effects of levodopa.

What is nausea and vomiting?

100

This enzyme inhibitor is combined with levodopa to prevent peripheral breakdown.

What is carbidopa?

200

This type of tremor typically affects the hands when they are at rest.

What is a resting tremor?

200

Levodopa competes with this type of nutrient for absorption in the small intestine.

What is protein?

200

This involuntary movement is a long-term side effect of levodopa.

What is dyskinesia?

200

Levodopa is converted into this neurotransmitter in the brain.

What is dopamine?

300

This term refers to the muscle stiffness found in Parkinsonism.

What is rigidity?

300

Levodopa is converted to dopamine in the brain using this enzyme

What is dopa decarboxylase?

300

A psychological side effect involving false beliefs or perceptions.

What is hallucinations or delusions?

300

What non-medication substance can affect how levodopa works?

What is protein or vitamin B6

400

This psychological side effect can cause a patient to gamble, disordered eating, and sexual behaviour.

Dopamine Dysregulation Syndrome

400

What prevents premature conversion of Levodopa in the periphery?

What is Carbidopa

400

This side effect increases fall risk.

What is orthostatic hypotension?

400

This is the reason levodopa doses often need to be increased over time.

What is tolerance or progression of disease?

500

This psychological impact is seen in 30%-50% of patients with PD

What is Depression and anxiety?

500

This is why levodopa needs to cross the blood-brain barrier.

What is to be converted into dopamine in the central nervous system?

500

Levodopa can cause this sudden, unpredictable "wearing off" phenomenon.

What is motor fluctuation?

500

The combination of carbidopa/levodopa is often sold under this brand name.

What is Sinemet?