Sitaglipton
Effects of Sitagliptin
What is: pancreatitis, severe ab, pain, upper respiratory tract infections, allergic reaction and rash
Effects of Canagliflozin
What is: weight loss g/t gluclosuria and caloric loss, increased urination, dehydration, UTIs, fungal infections
MOA of GLP-1
What is: stimulates insulin secretion, suppresses appetite, slows gastric emptying, suppresses after eating release of glucagon
Administration of Sitagliptin
What is: take in combo with metformin
MOA of Canagliflozin
What is: inhibits SGLT-2 in the kidneys, increases urinary glucose excretion, shown to prevent CV events and treat HF
Effects of GLP-1
What is: GI effects, rare pancreatitis, rare renal impairment
Patient education of Sitagliptin
What is: expensive, watch skin for rash, monitor pancreas, coughing from res. infection
Patient education of Canaliflozin
What is: slow postural changes, increased fluid intake, good personal hygiene
Contraindications of GLP-1
What is: hypoglycemia when given with sulfonylurea
MOA of Sitagliptin
What is: enhances incretin hormones, stimulates insulin secretion, suppresses after eating release if glucagon, given PO
Administration of Canaliflozin & T1/2
What is: given 1x a day & T1/2 is 12 hrs
Patient education of GLP-1
What is: wait an hr before giving oral meds d/t slowed gastric emptying, watch for N/V jaundice, ab. pain, monitor BUN, GFR, SR CR
Administration of GLP-1
What is: 1-2x daily