All about RCTs
Use P I C O format
What is the best approach to ask a clinical question?
What is meta analysis?
This medication is extracted from the autumn crocus
What is colchicine?
The T score that defines osteoporosis
What is -2.5 or less?
The use of these 2 drugs yield the best results for smoking cessation
What is NRT and Chantix?
External validity
What type of validity assesses the degree to which the results hold true in other settings?
It measures the amount of agreement between 2 study reviewers.
What is a kappa statistic?
Colchicine interferes with microtubule function and has an effect on these cells.
What is neutrophil and release of inflammatory chemokines?
The FRAX score that indicates the need to treat with alendronate in a patient with osteopenia.
What is a risk greater than 20% MOF or 3% hip fx?
2 recent RCTs in NEJM show that the use of this approach has the NNT of 7 to stop smoking cigarettes in one year
What is e-cigarettes?
The place you look to account for what happened to the patients in an RCT
What is the Consort Diagram?
The differences in study methods that affect the ability to combine data from different studies
What is heterogeneity?
The open label run-in period in the LoDoCo2 trial is an example of this type of bias.
What is selection bias?
The length of time you would treat a patient with osteoporosis with a po biphosphonate and with an IV biphosphonate
This scoring system consists of 6 questions that evaluate the quantity of cigarette consumption, the compulsion to use and dependence.
What is the Fagerstrom Test for Nicotine Dependence?
1/Absolute Risk Ratio
What is The Number Needed to Treat?
It is a measure of publication bias
In stable coronary disease colchicine decreased this outcome in several trials
What is composite of CV death, MI, CVA, and ischemia driven revascularization?
The drug of choice for treatment of osteoporosis in a patient with a GFR less than 30
What is Denosumab (Prolia)?
This medication no longer has a black box warning for use in patients with psychiatric illness
What is chantix?
It's considered the best way to analyze data in an RCT
What is Intention to Treat Analysis
It measures the heterogeneity between pooled studies
What is an I 2
Colchicine is contraindicated in patients with this impairment.
What is renal disease GFR<30
The FRAX risk score for Major Osteoporotic Fracture that requires a DEXA to be ordered.
What is greater than 8.4%?
The average number of attempts smokers make to quit prior to reaching prolonged abstinence