SICKLE CELL BASICS
Sickle cell disease is caused by a mutation in this gene.
HBB gene
This is another name for a sickle cell crisis.
Vaso-occlusive crisis
Name one energy conservation technique used in OT with SCD clients.
Activity pacing or rest breaks
This drug increases fetal hemoglobin and reduces crises
Hydroxyurea
Staying hydrated and avoiding this type of weather can help prevent a crisis.
Cold weather – Cold temps can trigger sickling and vaso-occlusion; staying warm and hydrated helps reduce risk
This abnormal type of hemoglobin causes red blood cells to sickle.
Hemoglobin S
Most common trigger for a vaso-occlusive crisis.
Dehydration or infection
What cognitive training technique helps people plan how they complete tasks?
Metacognitive strategy training
What is the name of the gene editing therapy showing promise in clinical trials?
CRISPR-Cas9
Using a visual planner or calendar can help with this part of daily routine.
Time and medication management – Helps with staying on schedule for meds, rest, and activities.
What shape do sickled cells take?
Crescent or sickle shape
What is a common symptom during a crisis that leads to ER visits?
Severe pain (pain crisis)
Amara’s OT suggested using this type of calendar for daily structure.
Visual daily planner
What therapy can potentially cure SCD in some patients but comes with risks?
Bone marrow or stem cell transplant
Sitting on a stool while cooking helps reduce this symptom.
Fatigue – Energy conservation strategies like seated tasks reduce muscle strain and exhaustion.
What does sickling of cells lead to in blood vessels?
Vaso-occlusion and inflammation
What dangerous chest condition mimics pneumonia and is common in SCD?
Acute Chest Syndrome
What kind of adaptations help manage school fatigue and pain?
Seated workstations, 504 plans
What is one benefit of blood transfusions in SCD?
Prevent stroke or treat severe anemia
This type of pain management tool can be used at home and doesn't involve medicine.
Warm compress/heat therapy – Common non-pharmacologic strategy for joint and muscle pain relief.
SCD is inherited in this genetic pattern.
Autosomal recessive
What kind of therapy is being trialed that may cure SCD at the genetic level?
CRISPR gene editing
According to AJOT (2023), what therapy improved self-management in teens with SCD?
ADAPT-SCD program
What pharmaceutical company is involved in current gene editing trials?
Vertex/CRISPR or Bluebird Bio
Students with SCD may qualify for this type of academic plan to support their education.
504 Plan – A legally binding school accommodation plan under Section 504 of the Rehabilitation Act.