Grant
What are inside vesicles in skeletal muscle?
Acetylcholine
Transverse Tubules (T-tubules)
Which Troponin sub-protein binds to Calcium?
Troponin C
What underlying disease if found in most patients with LEMS
Cancer
What breaks Acetylcholine and facilitates reuptake?
Acetylcholinesterase
What is the role of Dihydropyridine (DHP) receptor in excitation-contraction coupling?
It acts as a voltage sensor in the T-tubules that mechanically open the RyR (ryanodine receptor) on the sarcoplasmic reticulum to release Ca 2+
Protein that covers active binding site on Actin
This receptor is affect in people with LEMS disease:
Voltage Gated Calcium Channel
What else can bind to the nicotinic Acetylcholine receptor, that is not organically made by the body?
Nicotine
If DHP receptors failed to function properly, what specific step would be affected in muscle contraction?
Calcium would not be released from Sarcoplasmic reticulum, because the RyR channels would never open. Without calcium binding to troponin, cross-bridge cycling could not occur, leading muscle contraction to fail.
What does the abbreviation "SERCA" pump stand for? (You can logic this one out)
Sarcoplasmic/Endoplasmic Reticulum pump Ca 2+ ATPase
Who discovered LEMS disease?
Lamber and Eaton